Timeline of key events in Milstein's life

Date Event People Places
October 8, 1927Cesar Milstein was born in Bahia Blanca, ArgentinaMilsteinBahia Blanca, Argentina
1945 - 1952Cesar Milstein studies for a chemistry degreeMilsteinUniversity of Buenos Aires
1954 - 1958Cesar Milstein pursues his first doctorate in biochemistryMilstein, StoppaniUniversity of Buenos Aires
1957The Associacion Quimica Argentina awards Milstein a prize for the best doctoral thesis in chemistry that yearMilsteinUniversity of Buenos Aires
1957 - 1959Cesar Milstein publishes papers from his doctorate with his supervisor Andres StoppaniMilsteinUniversity of Buenos Aires
1958 - 1961Cesar Milstein takes up a British Council Scholarship at Cambridge UniversityMilstein, Dixon, WebbSir William Dunn School of Pathology
1961Cesar Milstein is awarded a second doctorate in biochemistry at Cambridge UniversityMilsteinSir William Dunn School of Pathology
1961Cesar Milstein takes up a position at the Instituto Malbran, Buenos AiresMilsteinInstituto Malbran
1962An Argentinian military coup throws Cesar Milstein's academic work into disarrayMilsteinInstituto Malbran
1963Cesar Milstein returns to Cambridge and begins researching the structure and diversity of antibodiesMilsteinLaboratory of Molecular Biology
1964Cesar Milstein publishes his first paper on antibodiesMilsteinLaboratory of Molecular Biology
July 1966Cesar Milstein and Sydney Brenner publish theory attributing antibody diversity to somatic mutationBrenner, MilsteinLaboratory of Molecular Biology
July 1970Cesar Milstein launches experiments to determine whether somatic mutation underlies antibody diversityCotton, Milstein, SecherLaboratory of Molecular Biology
1973Cesar Milstein meets Georges Kohler at the Basel Institute of ImmunologyKohler, MilsteinBasel Institute of Immunology
July 1973Cesar Milstein and Dick Cotton report the successful fusion of two different myeloma cell lines, one from a mouse and the other from a ratCotton, MilsteinLaboratory of Molecular Biology
June 1974Georges Kohler joins Cesar Milstein's research team to investigate somatic mutation and antibody diversityKohler, MilsteinLaboratory of Molecular Biology
January 1975Unlimited long-surviving monoclonal antibodies createdMilstein, KohlerLaboratory of Molecular Biology
1975 - 1979First monoclonal antibody created to target a neurotransmitter peptideMilstein, CuelloLaboratory of Molecular Biology, MRC Neurochemical Pharmacology Unit, Oxford University
August 1975First step taken to patent Kohler and Milstein's monoclonal antibodiesMilsteinLaboratory of Molecular Biology
August 7, 1975Cesar Milstein and Georges Kohler publish a paper outlining a technique for producing limitless monoclonal antibodiesKohler, MilsteinLaboratory of Molecular Biology

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