This website provides a curated collection of resources about the people, places and technologies that have enabled biotechnology to transform our healthcare and the world we live in today

Timeline of key events

Timeline of key events in biotechnology

To search for particular terms in the description of the event enter the term in the box below 'Event' on the table and press 'enter'. Alternatively use the dropdown lists to filter by Person, Place or Science. Click here to clear the filter.

Date Event People Places Sciences
11 Dec 2015Preliminary results presented for phase 2 trial using Zinc finger nuclease modified CD4 and CD8 cells to treat HIV patients  Sangamo BiosciencesGene therapy, Gene editing, Zinc fingers
23 Dec 2015Alfred G Gilman diedGilman Cell
31 Dec 2015CRISPR successfully used to improve muscle function in mouse model of Duchenne muscular dystrophy, opening way to use CRISPR to correct genetic mutatiuons in affected tissues of sick patientsNelson, Gersbach, Hakim, Ousterout, ThakoreDuke University, University of Missouri, University of North Carolina, Massachusetts Institute of Technology, Harvard UniversityCRISPR-Cas9, Gene editing, Gene therapy
06 Jan 2016Harvard scientists published improved version of CRISPR/Cas 9 with less risk of off-target DNA breaksKleinstiver, Pattanayak, Prew, Tsai, Nguyen, Zheng, JoungHarvard UniversityCRISPR-Cas9, Gene editing
01 Feb 2016UK scientists authorised to genetically modify human embryos using CRISPR-Cas 9NiakanCrick InstituteCRISPR-Cas9
08 Mar 2016UK scientists link repeated miscarriages to a reduction of stem cells in lining of the wombBrosens, QuenbyUniversity of WarwickStem Cells
09 Mar 2016A dozen infants born with cataracts reported to regain sight after receiving new stem cell therapy to regenerate healthy lenses in their eyes. ZhangUniversity of California San DiegoStem Cells
17 Mar 2016Scientists announce the first generation of an embryonic stem cell that carries a single copy of the human genome rather than the usual twoEgli, Benvinsty, Sagi, Chia, Golan-Lev, Peretz, Weissbein, Sui, Sauer, YanukkaColumbia UniversityStem cells
23 Mar 2016Surgeon involved in world's first trachea transplant made from patient's own stem cells sacked for scientific misconductMacchiariniKarolinska InstituteStem cells
25 Mar 2016Common tags discovered on the surface of cancer cells opening up new avenues for immunotherapyMcGranahan, Furness, Rosenthal, Ramskov, Lyngaa, Saini, Jamal-Hanjani, Wilson, Birkbak, Hiley, Watkins, Shafi, Murugaesu, Mitter, Akarca, Linares, Marafioti, Henry, Van Allen, Miao, Schilling, Schadendorf, Garraway, Makarov, Rizvi,m Snyder, Hellman, MerghUniversity College London, Cancer Research UK, Francis Crick Insitute, Dana-Farber Cancer Institute, Broad Institute, University Duisburg-Essen, Memorial Sloan Kettering Cancer Center, Columbia Univertsity, Weill Cornell Medical College, Harvard Medical SImmunology, Immunotherapy, Oncology
15 Apr 2016Gene editing used to prompt immune cells to combat cancerQuezada, Johnson, Menger, Sledzinska, Bergerhoff, Vargas, Smith, Poirot, Pule, Hererro, PeggsUniversity College London, Cancer Research UK, CellectisImmunology, Oncology, TALENs, Gene editing, Immunotherapy
01 May 2016FDA approved atezolizumab (Tecentriq®), an immune checkpoint inhibitor targeted at PD1, for the treatment of urothelial carcinoma, the most common form of bladder cancer Genentech, RocheImmune checkpoint inhibitor, Immuotherapy, Oncology, Monoclonal antibodies
02 Jun 2016Stem cells reported to provide substantial recovery in patients disabled by stroke Stanford UniversityStem cells
13 Jun 2016Beverly Griffin diedGriffinImperial College 
21 Jun 2016US NIH Recombinant DNA Advisory Committee approved first study in 15 patients using CRISPR/Cas 9 to genetically modify immune cells to attack cancerJuneUniversity of PennsylvaniaCRISPR-Cas9, Gene editing, Gene therapy, Immunotherapy
23 Jun 2016FDA approved first clinical trial for zika virus vaccineWeinerWistar Institute, University of Pennsylvania, Inovio Pharmaceuticals, GeneOne Life Science, Public Health Agency of CanadaVaccines, Virology
24 Jul 2016Small-scale case study showed power of stem cells to repair damaged scar tissue caused by heart attacksAnastasiadis, Antonitsis, Westaby, Reginald, Sultan, Doumas, Efthimiadis, EvansAHEPA University Hospital, Oxford University, Cardiff UniversityStem cells
Aug 2016Marker identified for myeloid-derived suppressor cells, a type of cell associated with tumour resistance to certain cancer treatments Wistar InstituteImmunology, Immunotherapy, Oncology
01 Sep 2016Monoclonal antibody drug for Alzheimer's Disease shown to be promising in phase II clinical trialsSevigny, Chiao, Bussiere, WeinrebBiogen, Neuimmune, Butler Hospital, University of ZurchMonoclonal antibodies, Neuroscience
03 Oct 2016Nobel Prize in Physiology or medicine was awarded to Yoshinori Ohsumi for discovering how the body's cells destroy and recyle cellular components, a process known as autophagyOhsumi Tokyo Institute of Technology'Cell

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