This website provides a curated collection of resources about the people, places and technologies that have enabled biotechnology to transform our healthcare and the world we live in today

Timeline of key events

Timeline of key events in biotechnology

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Date Event People Places Sciences
Feb 1969Team led by Karl and Ingegerd Hellstrom observe serum from mice with chemically induced tumours can block reaction of lymphocytesHellstrom, Evans, Heppner, Pierce, Yang Fred Hutchinson Cancer CenterImmune checkpoint inhibitors, Immunotherapy, Oncology
Jul 1969Discovery of methylase, an enzyme, found to add protective methyl groups to DNAArber, LinnUniversity of GenevaDNA methylation, Epigenetics
1970 - 1972Means developed for cloning B cells that produce single antibodies with known specificityAskonas, Williamson, WrightNational Institute for Medical ResearchMonoclonal antibodies
1970Fluorescence activated cell sorter createdHerzenbergStanford UniversityAntibodies
1970First complete gene synthesised KhoranaUniversity of Wisconsinrecombinant DNA, DNA
Jul 1970Cesar Milstein launches experiments to determine whether somatic mutation underlies antibody diversityCotton, Milstein, SecherLaboratory of Molecular BiologyAntibodies
Jul 1970First restriction enzyme isolated and characterisedSmith, WilcoxJohns Hopkins UniversityRestriction enzymes, Recombinant DNA, DNA Sequencing
1971Sera-Lab foundedMurray Monoclonal antibodies
1971Cetus Corporation, the first biotechnology was foundedCape, Farley, GlaserCetusStem cells
1971Process called repair replication for synthesising short DNA duplexes and single-stranded DNA by polymerases is publishedKhorana, KleppeMITPCR, DNA Sequencing
1971First plasmid bacterial cloning vector constructedBerg, Mertz, JacksonStanford UniversityRecombinant DNA
May 1971Complete sequence of bacteriophage lambda DNA reportedWu, TaylorCornell UniversityDNA Sequencing
Jun 1971First time potential biohazards of recombinant DNA raisedMertz, Berg, PollackStanford UniversityRecombinant DNA
Jun 1971Hellstom team suggest that antibodies bound to tumour cells mask their detection by the immune system Sjogren, Hellstrom, BansalFred Hutchinson Cancer CenterImmune checkpoint inhibitors, Immunotherapy, Oncology
15 Jun 1971Wendell M Stanley diedStanleyRockefeller UniversityBiochemistry
01 Jul 1971William Lawrence Bragg died  X ray crystallography
21 Sep 1971Bernardo Alberto Houssay diedHoussay University of Buenos AiresMetabolism
29 Oct 1971Arne W K Tiselius diedTiseliusUppsala UniversityBiochemistry
Dec 1971First experiments published demonstrating the use of restriction enzymes to cut DNADanna, NathansJohns Hopkins UniversityRestriction enzymes, Recombinant DNA, DNA Sequencing
1972US National Cancer Institute recommended creation of international registry of immunotherapy trials  Immunotherapy, Oncology

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