This website provides a curated collection of resources about the people, places and technologies that have enabled biotechnology to transform our healthcare and the world we live in today

Timeline of key events

Timeline of key events in biotechnology

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Date Event People Places Sciences
09 Mar 1974Earl W Sutherland diedSutherlandVanderbilt UniversityCell
Jun 1974Georges Kohler joins Cesar Milstein's research team to investigate somatic mutation and antibody diversityKohler, MilsteinLaboratory of Molecular BiologyMonoclonal antibodies
Jul 1974First concerns about potential biohazards of recombinant DNA publishedBerg, Baltimore, Boyer, Cohen Recombinant DNA
1975Temporary moratorium on genetic engineeringBerg Recombinant DNA
Jan 1975Unlimited long-surviving monoclonal antibodies createdMilstein, KohlerLaboratory of Molecular BiologyMonoclonal antibodies
1975Short-lasting antibodies against influenza virus devisedGerhardWistar InstituteMonoclonal antibodies
1975 - 1979First monoclonal antibody created to target a neurotransmitter peptideMilstein, CuelloLaboratory of Molecular Biology, MRC Neurochemical Pharmacology Unit, Oxford UniversityMonoclonal antibodies
1975A liquid media is developed for growing bone marrow cells, including the blood stem cellDexterPaterson Institute for Cancer ResearchStem cells
1975Sanger and Coulson publish their plus minus method for DNA sequencingSanger, CoulsonLaboratory of Molecular BiologyDNA Sequencing
1975DNA methylation suggested as mechanism behind X-chomosome silencing in embryosRiggs, Sager, KitchenCity of Hope National Medical Center, Harvard UniversityDNA methylation, Epigenetics, Embryology
1975DNA methylation proposed as important mechanism for the control of gene expression in higher organismsHoilliday, PughNational Institute for Medical ResearchDNA methylation, Epigenetics
Feb 1975Natural killer cell identified in mice and shown to be important part of immune systemKiessling, Klein, Pross, WigzellKarolinska InstituteImmunology, Immunotherapy, Oncology
15 Apr 1975Human natural killer cell isolatedJondal, ProssKarolinska InstituteImmunology, Immunotherapy, Oncology
19 Apr 1975Percy Lavon Julian diedJulianHarvard UniversityPharmacology
24 Apr 1975Discovery of unique molecular marker, idiotype, on blood cancer cells, opening new avenue for cancer diagnosis and therapyStevensonTenovus Research LaboratoryImmunology, Immunotherapy, Oncology
Apr 1975Unique marker, known as an idiotypic determinant, discovered on the surface of proteins in cancer cells, providing a new target for treating cancerStevensonSouthampton UniversityAntibodies
Aug 1975First step taken to patent Kohler and Milstein's monoclonal antibodiesMilsteinLaboratory of Molecular BiologyMonoclonal antibodies
07 Aug 1975Cesar Milstein and Georges Kohler publish a paper outlining a technique for producing limitless monoclonal antibodiesKohler, MilsteinLaboratory of Molecular BiologyMonoclonal antibodies
Sep 1975Tumour necrosis factor (TNF) was discovered. It was the first immune molecule shown to kill cancer cellsCarswell, Old, Kassel, Green, Fiore, WilliamsonMemorial Sloan Kettering Cancer CenterImmunology, Immunotherapy, Oncology, Monoclonal antibodies
05 Nov 1975Edward Lawrie Tatum diedTatumRockefeller UniversityGenetics

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