This website provides a curated collection of resources about the people, places and technologies that have enabled biotechnology to transform our healthcare and the world we live in today

Timeline of key events

Timeline of key events in biotechnology

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Date Event People Places Sciences
22 Nov 1981Hans Adolf Krebs diedKrebs Sheffield UniversityCell, Biochemistry
1982First international workshop on human differentiation antigens establishes international code for classifying and coding monoclonal antibodiesBoumsell, BernardSaint-Louis HospitalMonoclonal antibodies
1982Monoclonal antibodies generated for routine use in ABO blood typingLennox, Milstein, Sacks, VoakLaboratory of Molecular Biology, Addenbrookes HospitalMonoclonal antibodies
1982Marrow stem cells shown to be distinct from progenitor cells   Stem cells
1982AIS, the first biotechnology company to commercialise blood stem cell-based innovation is established AISStem cells
1982Whole genome sequencing method is introduced for DNA sequencing  Sequencing DNA
22 Apr 1982First experiment launched to test feasibility of inserting a corrective DNA in the right place in the human genomeSmithiesUniversity of WisconsinGene editing, Gene Therapy
Jun 1982NIH agrees to provide US$3.2 million over 5 years to establish and maintain a nucleic sequence database  Sequencing DNA
Jun 1982Steven Rosenberg and colleagues first describe lymphokine-activated killer cellsGrimm, Mazumder, Zhang, RosenbergNational Cancer InstituteImmunology, Immunotherapy, Oncology
15 Aug 1982Axel H T Theorell diedTheorellKarolinska Institutet,Biochemistry
Oct 1982First recombinant DNA based drug approved Genentech IncRecombinant DNA
Nov 1982James Allison and collegues use monoclonal antibody to provide first biochemical description of tumour specific antigen of murine T-lymphomaAllison, McIntyre, BlochUniversity of Texas System Cancer CenterImmunology, Immunotherapy, Monoclonal antibodies, Oncology
Dec 1982Giant mice made with the injection of rat growth hormoneBrinster, PalmiterUniversity of Pennsylvania, University of Washington SeattleTransgenic animals
01 Dec 1982First molecular markers, antigens, identified in melanoma tumours. These markers are now targeted by cancer drugsHoughton, Eisinger, Albino, Cairncross, OldMemorial Sloan Kettering Cancer CenterImmunology, Immunotherapy, Oncology
1983First bispecific monoclonal antibody producedCuello, MilsteinLaboratory of Molecular Biology, Oxford UniversityMonoclonal antibodies
1983Course started in the molecular embyology of miceCostantini, Hogan, Lacy Cold Spring Harbour Laboratory, NIMR, Sloan Kettering Cancer Research Center, Columbia UniversityTransgenic animals
1983Sanger retiresSangerLaboratory of Molecular BiologySequencing DNA
1983Link drawn between immune deficiency and cancer  Memorial Sloan Kettering Cancer CenterImmunology, Oncology, Virology
1983Murine p53 gene clonedLevine, OrenWeizmann Institute, State University New YorkOncology, p53
Jan 1983Official naming of p53Crawford, Pim, Gurney, Goodfellow, Taylor-PapdimitriouImperial Cancer Research Fundp53

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