This website provides a curated collection of resources about the people, places and technologies that have enabled biotechnology to transform our healthcare and the world we live in today

Timeline of key events

Timeline of key events in biotechnology

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Date Event People Places Sciences
20 Jan 1983Solomon Spiegelman diedSpiegelmanUniversity of MinnesotaRecombinant DNA
05 Feb 1983Margaret Dayhoff died in Silver Spring, Maryland, USADayhoff  
10 Feb 1983Discovery of mouse strain with severe combined immune deficiency, providing valuable research model for investigating diseases like cancer and HIVBosma, CusterFox Chase Cancer CenterImmunology, Oncology
19 Feb 1983William Clouser Boyd diedBoydBoston UniversityImmunology
09 Mar 1983Ulf von Euler diedvon EulerKarolinska InstituteNeuroscience
24 Mar 1983First cloning of Interleukin 2 (Il-2)Taniguchi, Matsui, Fujita, Takaoka, Kashmina, Yoshimoto, HamuroJapanese Foundation for Cancer Research, Ajinomoto Co IncImmunology, Immunotherapy, Oncology
1983Polymerase chain reaction (PCR) starts to be developed as a technique to amplify DNAMullisCetus CorporationPCR, Sequencing DNA
22 May 1983Albert Claude died Claude  
Jun 1983Harald Zur Hausen identifies the human papillomavirus as the causative agent of cervical cancerzur HausenUniversity of FreibergOncology, Virology
Nov 1983A team of researchers including Philippa Marrack, John Kappler and James P Allison identified the T cell antigen receptorKappler, Kubo, Haskins, Hannum, Marrack, Pigeon, McIntyre, Allison, TrowbridgeUniversity of Colorado, University of Texas System Cancer Center, National Jewish Hospital and Research Cener, Salk InstituteImmunology, Immunotherapy, Oncology
16 Dec 1983New method published for measuring antigen-specific T cell responses enabling clinical trial immune monitoringCzerkinsky, Nilsson, Nygren, Ouchterlony, TarkowskiUniversity of GoteborgImmunology
1984A molecular marker, CD34, is identified as specific for a subset of marrow cells containing the blood stem cellCivinJohns HopkinsStem cells
1984CD34 marker used as the basis for cell separation technology  Stem cells
1984Blood stem cells extensively purified for first time  Stem cells
1984First mouse clone claim challenged University of GenevaCloning
1984Antisense RNA shown to inhibit gene activityIzzant, Weintraub, Rubenstein, NicolasFred Hutchinson Cencer Research Center, University of California San FranciscoRNA interference
1984Experiment published demonstrating possibility of inserting a corrective DNA in the right place in genome of mammalian cellsSmithies, Koralewski, Song, KucherlapatiUniversity of WisconsinGene eding, Gene Therapy
1984Experiments show that injections with T-cell growth factor interleukin-2 can shrink tumours in humansRosenbergNational Cancer InstituteImmunotherapy
1984p53 inactivated in tumour cells for first timeWolf, RotterWeizmann InstituteOncology, p53
1984Human p53 gene clonedMatlashewski, Lamb, Pim, Peacock, Crawford, BenchimoImperial Cancer Research Fund Laboratories, Ontario Cancer Institute, University of TorontoOncology, p53

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