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Timeline of key events

Timeline of key events in biotechnology

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Date Event People Places Sciences
Jun 1982NIH agrees to provide US$3.2 million over 5 years to establish and maintain a nucleic sequence database  DNA Sequencing
Jun 1982Steven Rosenberg and colleagues first describe lymphokine-activated killer cellsGrimm, Mazumder, Zhang, RosenbergNational Cancer InstituteImmunology, Immunotherapy, Oncology
15 Aug 1982Axel H T Theorell diedTheorellKarolinska Institutet,Biochemistry
Oct 1982First recombinant DNA based drug approved Genentech IncRecombinant DNA
Nov 1982James Allison and collegues use monoclonal antibody to provide first biochemical description of tumour specific antigen of murine T-lymphomaAllison, McIntyre, BlochUniversity of Texas System Cancer CenterImmunology, Immunotherapy, Monoclonal antibodies, Oncology
Dec 1982Giant mice made with the injection of rat growth hormoneBrinster, PalmiterUniversity of Pennsylvania, University of Washington SeattleTransgenic animals
01 Dec 1982First molecular markers, antigens, identified in melanoma tumours. These markers are now targeted by cancer drugsHoughton, Eisinger, Albino, Cairncross, OldMemorial Sloan Kettering Cancer CenterImmunology, Immunotherapy, Oncology
1983First bispecific monoclonal antibody producedCuello, MilsteinLaboratory of Molecular Biology, Oxford UniversityMonoclonal antibodies
1983Course started in the molecular embyology of miceCostantini, Hogan, Lacy Cold Spring Harbour Laboratory, NIMR, Sloan Kettering Cancer Research Center, Columbia UniversityTransgenic animals
1983Sanger retiresSangerLaboratory of Molecular BiologyDNA Sequencing
1983Link drawn between immune deficiency and cancer  Memorial Sloan Kettering Cancer CenterImmunology, Oncology, Virology
1983Murine p53 gene clonedLevine, OrenWeizmann Institute, State University New YorkOncology, p53
Jan 1983Official naming of p53Crawford, Pim, Gurney, Goodfellow, Taylor-PapdimitriouImperial Cancer Research Fundp53
06 Jan 1983Widespread loss of DNA methylation found on cytosine-guanine (CpG) islands in tumour samplesFeinberg, VogelsteinJohns Hopkins UniversityDNA methylation, Epigenetics
20 Jan 1983Solomon Spiegelman diedSpiegelmanUniversity of MinnesotaRecombinant DNA
05 Feb 1983Margaret Dayhoff died in Silver Spring, Maryland, USADayhoffSilver Spring, Maryland 
10 Feb 1983Discovery of mouse strain with severe combined immune deficiency, providing valuable research model for investigating diseases like cancer and HIVBosma, CusterFox Chase Cancer CenterImmunology, Oncology
19 Feb 1983William Clouser Boyd diedBoydBoston UniversityImmunology
09 Mar 1983Ulf von Euler diedvon EulerKarolinska InstituteNeuroscience
24 Mar 1983First cloning of Interleukin 2 (Il-2)Taniguchi, Matsui, Fujita, Takaoka, Kashmina, Yoshimoto, HamuroJapanese Foundation for Cancer Research, Ajinomoto Co IncImmunology, Immunotherapy, Oncology

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