Timeline of key events in biotechnology

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Based on investigation of blood drawn from AIDS patients who developed Kaposi sarcoma, a cancer caused by a virus. The research was carried out by Susan Krown and Bijan Safai.1983-01-01T00:00:00+0000M Oren, A J Levine, 'Molecular cloning of a cDNA specific for the murine p53 cellular tumor antigen', PNAS, 80 (1983), 56–9. 1983-01-01T00:00:00+0000LV Crawford, DC Pim, EG Gurney, P Goodfellow, J Taylor-Papaidmitriou,'The 53,000-dalton cellular protein and its role in transformation', International Review of Experimental Pathology, 25 (1983) 1-50. 1983-01-01T00:00:00+0000A.P. Feinberg, B. Vogelstein, 'Hypomethylation distinguishes genes of some human cancers from their normal counterparts', Nature, 301/5895 (1983), 89-92.1983-01-06T00:00:00+0000Speigelman developed the nucleic acid hybridization technique that enables specific DNA and RNA strands to be removed from cells and is the foundation of present day recombinant DNA technology. 1983-01-20T00:00:00+0000Dayhoff is known as the founder of bioinformatics. This she did by pioneering the application of mathematics and computational techniques to the sequencing of proteins and nucleic acids and establishing the first publicly available database for research in the area. 1983-02-05T00:00:00+0000GC Bosma, RP Custer, MJ Bosma, 'A severe combined immunodeficiency mutation in the mouse', Nature, 301 (1983), 527-30. 1983-02-10T00:00:00+0000Boyd was an American immunologist who helped discover blood types are an inherited trait1983-02-19T00:00:00+0000Von Euler shared the 1970 Nobel Prize for Medicine for 'discoveries concerning the humoral transmittors in the nerve terminals and the mechanism for their storage, release and inactivation.'1983-03-09T00:00:00+0000T Taniguchi et al, 'Structure and expression of a cloned cDNA for human interleukin-2', Nature, 302 (1983), 305-10.1983-03-24T00:00:00+0000Kary Mullis, an American biochemist based at Cetus, proposed an alternative method to Sanger's DNA sequencing method to analyse Sickle cell Anaemia mutation which laid the foundation for the development of the PCR technique. 1983-05-01T00:00:00+0000Murine leukaemia retrovirus genetically modified to produce the vector. R. Mann, R.C. Milligam, D. Baltimore, ‘Construction of a Retrovirus Packaging Mutant and Its Use to Produce Helper-Free Defective Retrovirus’, Cell, 33/1 (1983), 153-59.1983-05-01T00:00:00+0000Claude shared the 1974 Nobel Prize for Medicine for discoveries concerning cell structure and function. 1983-05-22T00:00:00+0000M Durst, L Gissmann, H Ikenberg, H zur Hausen, 'A papillomavirus DNA from a cervical carcinoma and its prevalence in cancer biopsy samples from different geographic regions', Proc Natl Acad Sci USA, 80 (1983), 3812-15.1983-06-01T00:00:00+0000J Kappler et al, 'The major histocompatibility complex-restricted antigen receptor on T cells in mouse and man', Cell, 35 (1983), 295-02. 1983-11-01T00:00:00+0000C Czerkinsky, L Nilsson, H Nygren, O Ouchterlony, A Tarkowski, 'A solid-phase enzyme-linked immunospot (ELISPOT) assay for enumeration of specific antibody-secreting cells', Journal of Immunology Methods, 65/1-2 (1983), 109-21.1983-12-16T00:00:00+0000Identified by Curt Civin and his team at Johns Hopkins, the subset of cells bearing the CD34 (surface) marker is shown also to contain other kinds of cell. The research shows that the blood stem cell can be enriched for, but not purified. The advance proves useful in the clinical setting where enrichment for the CD34 cell can aid faster recovery of the blood system in patients undergoing chemotherapy and/or bone marrow transplants for serious blood disorders. 1984-01-01T00:00:00+00001984-01-01T00:00:00+00001984-01-01T00:00:00+0000 Illmensee’s 1981 announcement of cloning mice is believed to be fraudulent1984-01-01T00:00:00+0000
Date Event People Places Sciences
1983Link drawn between immune deficiency and cancer  Memorial Sloan Kettering Cancer CenterImmunology, Oncology, Virology
1983Murine p53 gene clonedLevine, OrenWeizmann Institute, State University New YorkOncology, p53
Jan 1983Official naming of p53Crawford, Pim, Gurney, Goodfellow, Taylor-PapdimitriouImperial Cancer Research Fundp53
6 Jan 1983Widespread loss of DNA methylation found on cytosine-guanine (CpG) islands in tumour samplesFeinberg, VogelsteinJohns Hopkins UniversityDNA methylation, Epigenetics
20 Jan 1983Solomon Spiegelman diedSpiegelmanUniversity of MinnesotaRecombinant DNA
5 Feb 1983Margaret Dayhoff died in Silver Spring, Maryland, USADayhoffSilver Spring, Maryland 
10 Feb 1983Discovery of mouse strain with severe combined immune deficiency, providing valuable research model for investigating diseases like cancer and HIVBosma, CusterFox Chase Cancer CenterImmunology, Oncology
19 Feb 1983William Clouser Boyd diedBoydBoston UniversityImmunology
9 Mar 1983Ulf von Euler diedvon EulerKarolinska InstituteNeuroscience
24 Mar 1983First cloning of Interleukin 2 (Il-2)Taniguchi, Matsui, Fujita, Takaoka, Kashmina, Yoshimoto, HamuroJapanese Foundation for Cancer Research, Ajinomoto Co IncImmunology, Cancer immunotherapy, Oncology
1983Polymerase chain reaction (PCR) starts to be developed as a technique to amplify DNAMullisCetus CorporationPCR, DNA Sequencing
May 1983Creation of first retroviral vector suitable for gene therapyMann, Mulligan, BaltimoreMassachusetts Institute of Technology, Whitehead Institute for Biomedical ResearchGene therapy
22 May 1983Albert Claude died Claude  
Jun 1983Harald Zur Hausen identifies the human papillomavirus as the causative agent of cervical cancerzur HausenUniversity of FreibergOncology, Virology
Nov 1983A team of researchers including Philippa Marrack, John Kappler and James P Allison identified the first T cell antigen receptorKappler, Kubo, Haskins, Hannum, Marrack, Pigeon, McIntyre, Allison, TrowbridgeUniversity of Colorado, University of Texas System Cancer Center, National Jewish Hospital and Research Cener, Salk InstituteImmunology, Cancer immunotherapy, Oncology
16 Dec 1983New method published for measuring antigen-specific T cell responses enabling clinical trial immune monitoringCzerkinsky, Nilsson, Nygren, Ouchterlony, TarkowskiUniversity of GoteborgImmunology
1984A molecular marker, CD34, is identified as specific for a subset of marrow cells containing the blood stem cellCivinJohns HopkinsStem cells
1984CD34 marker used as the basis for cell separation technology  Stem cells
1984Blood stem cells extensively purified for first time  Stem cells
1984First mouse clone claim challenged University of GenevaCloning

1983

Link drawn between immune deficiency and cancer

1983

Murine p53 gene cloned

Jan 1983

Official naming of p53

6 Jan 1983

Widespread loss of DNA methylation found on cytosine-guanine (CpG) islands in tumour samples

20 Jan 1983

Solomon Spiegelman died

5 Feb 1983

Margaret Dayhoff died in Silver Spring, Maryland, USA

10 Feb 1983

Discovery of mouse strain with severe combined immune deficiency, providing valuable research model for investigating diseases like cancer and HIV

19 Feb 1983

William Clouser Boyd died

9 Mar 1983

Ulf von Euler died

24 Mar 1983

First cloning of Interleukin 2 (Il-2)

1983

Polymerase chain reaction (PCR) starts to be developed as a technique to amplify DNA

May 1983

Creation of first retroviral vector suitable for gene therapy

22 May 1983

Albert Claude died

Jun 1983

Harald Zur Hausen identifies the human papillomavirus as the causative agent of cervical cancer

Nov 1983

A team of researchers including Philippa Marrack, John Kappler and James P Allison identified the first T cell antigen receptor

16 Dec 1983

New method published for measuring antigen-specific T cell responses enabling clinical trial immune monitoring

1984

A molecular marker, CD34, is identified as specific for a subset of marrow cells containing the blood stem cell

1984

CD34 marker used as the basis for cell separation technology

1984

Blood stem cells extensively purified for first time

1984

First mouse clone claim challenged