This website provides a curated collection of resources about the people, places and technologies that have enabled biotechnology to transform our healthcare and the world we live in today

Timeline of key events

Timeline of key events in biotechnology

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Date Event People Places Sciences
1983Polymerase chain reaction (PCR) starts to be developed as a technique to amplify DNAMullisCetus CorporationPCR, DNA Sequencing
22 May 1983Albert Claude died Claude  
Jun 1983Harald Zur Hausen identifies the human papillomavirus as the causative agent of cervical cancerzur HausenUniversity of FreibergOncology, Virology
Nov 1983A team of researchers including Philippa Marrack, John Kappler and James P Allison identified the T cell antigen receptorKappler, Kubo, Haskins, Hannum, Marrack, Pigeon, McIntyre, Allison, TrowbridgeUniversity of Colorado, University of Texas System Cancer Center, National Jewish Hospital and Research Cener, Salk InstituteImmunology, Immunotherapy, Oncology
16 Dec 1983New method published for measuring antigen-specific T cell responses enabling clinical trial immune monitoringCzerkinsky, Nilsson, Nygren, Ouchterlony, TarkowskiUniversity of GoteborgImmunology
1984A molecular marker, CD34, is identified as specific for a subset of marrow cells containing the blood stem cellCivinJohns HopkinsStem cells
1984CD34 marker used as the basis for cell separation technology  Stem cells
1984Blood stem cells extensively purified for first time  Stem cells
1984First mouse clone claim challenged University of GenevaCloning
1984Antisense RNA shown to inhibit gene activityIzzant, Weintraub, Rubenstein, NicolasFred Hutchinson Cencer Research Center, University of California San FranciscoRNA interference
1984Experiment published demonstrating possibility of inserting a corrective DNA in the right place in genome of mammalian cellsSmithies, Koralewski, Song, KucherlapatiUniversity of WisconsinGene eding, Gene Therapy
1984Experiments show that injections with T-cell growth factor interleukin-2 can shrink tumours in humansRosenbergNational Cancer InstituteImmunotherapy
1984p53 inactivated in tumour cells for first timeWolf, RotterWeizmann InstituteOncology, p53
1984Human p53 gene clonedMatlashewski, Lamb, Pim, Peacock, Crawford, BenchimoImperial Cancer Research Fund Laboratories, Ontario Cancer Institute, University of TorontoOncology, p53
03 Feb 1984First human baby born from embryo transferBuster Embyology
Jun 1984Results from PCR experiments start being reportedMullisCetus CorporationPCR, DNA Sequencing
Jun 1984First clinical experiments demonstrate the possibility of training T cells to attack tumoursKnuth, Danowski, Oettgen, OldMemorial Sloan-Kettering Cancer CenterImmunology, Immunotherapy, Oncology
1984First chimeric monoclonal antibodies developed which lays foundation for safer and more effective monoclonal antibody therapeuticsNeuberger, Rabbitts, Morrison, Oi, Herzenberg, Boulianne, Schulman, HozumiLaboratory of Molecular Biology, Stanford Univerity Medical SchoolMonoclonal antibodies, Recombinant DNA
1985Antibody genes identifiedTonegawaBasel Institute of ImmunologyMonoclonal antibodies
1985Phage display method is developed for selecting peptides, proteins or antibodies from a wide number of variants.SmithUniversity of MissouriPhage Display

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