This website provides a curated collection of resources about the people, places and technologies that have enabled biotechnology to transform our healthcare and the world we live in today

Timeline of key events

Timeline of key events in biotechnology

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Date Event People Places Sciences
1986Discovery of RNA interference (RNAi)Jorgensen, NapoliAdvanced Genetic SciencesRNA interference
14 Feb 1986Gene targeting technique used to correct defective gene in the chromosome of a mammalian cellThomas, Folger, CapecchiUniversity of UtahGene editing
Apr 1986Human Genome Organization founded  Sequencing DNA, Genomics
May 1986First humanised monoclonal antibody createdDear, Foote, Jones, Neuberger, WinterLaboratory of Molecular BiologyMonoclonal antibodies, Recombinant DNA
Jun 1986Interferon approved for treating hairy cell leukaemia  Recombinant DNA, Monoclonal antibodies
Jun 1986First monoclonal antibody drug approvedChang, Kung, Gringas, Schlossman, Goldstein  Monoclonal antibodies
Jun 1986Co-ordinated US regulatory framework esablished for biotechnology  Regulation
Jul 1986First recombinant vaccine licensed Merck & CoRecombinant DNA, Vaccine
24 Jul 1986Fritz A Lipmann diedLipmann Nutrition
22 Oct 1986Albert Szent-Gyorgyi von Nagyrapolt diedSzent-Gyorgyi Szeged UniversityCell
Dec 1986Anti-tumour responses observed in 3 out of 10 patients given high-doses of Interleukin-2 (IL-2) Rosenberg, Lotze, Chang, Seipp, Simpson, VettoNational Cancer InstituteImmunology, Immunotherapy, Oncology
30 Dec 1986Reinhold Benesch diedBeneschColumbia UnivesityBiochemistry
1987First clinical trials of foetal neural cell grafting in patients with Parkinson’s diseaseBjorklund, Lindvall Lund UniversityStem cells
1987 - 1989Scientists lay the foundation for the cloning of human tumour antigens recognised by cytotoxic T lymphocytes, a type of white blood cell that kills cancer cellsDe Plaen, BoonLudwig Institute for Cancer ResearchImmunology, Immunotherapy, Oncology
15 Mar 1987First stable human anti-tumour cytotoxic T cell clones isolated and maintained in cultureHerin, Lemoine, Weynants, Vessiere, Van Pel, Knuth, Devos, BoonLudwig InstituteImmunology, Immunotherapy, Oncology
Apr 1987CD8 coreceptor proven to be actively involved in antigen recognition by killer T cellsDembic, Haas, Zamoyska, Parnes, Steinmetz, von BoehmerBasel Institute of ImmunologyImmunology, Immunotherapy, Oncology
09 Apr 1987Successful results reported for trial using the cytokine IL-2 and lymphokine-activated killer cells to treat cancerRosenbergNational Cancer InstituteImmunotherapy
May 1987John H Northrop diedNorthrop  
Jun 1987The patent for PCR with Taq ploymerase is filedMullis  
Jul 1987Identification of the cytotoxic T lymphocyte-associated antigen 4 (CTLA-4)Brunet, Denizot, Luciani, Roux-Dosseto, Suzan, Mattei, GolsteinINSERM-CNRSImmunology, Immunotherapy, Oncology

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