This website provides a curated collection of resources about the people, places and technologies that have enabled biotechnology to transform our healthcare and the world we live in today

Timeline of key events

Timeline of key events in biotechnology

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Date Event People Places Sciences
Jan 1985 - May 1987Cetus developed PCR for measuring amount of HIV circulating in blood Cetus CorporationPCR
Jan 1985Idea put forward for the creation of transgenic mice to produce human antibodiesAlt, Blackwell, YancopoulosColumbia UniversityMonoclonal antibodies, gene cloning
1985First transgenic mice created with with genes coding for both the heavy and light chain domains in an antibody.Kohler, RusconiMax-Planck InstituteTransgenic animals, Monoclonal antibodies
1985Discovery of the first zinc finger nuclease, a site-specific endonuclease (enzyme) designed to bind and cleave DNA at specific positionsMiller, McLachlan, KlugLaboratory of Molecular BiologyGene editing, Zinc fingers
1985T cell surface proteins CD4 and CD8 cloned Maddon, Littman, Godfrey, Maddon Chess, AxelColumbia UniversityImmunology, Immunotherapy, Oncology
Jan 1985DNA methylation found to occur on specific DNA segments called CpG islandsBird, Taggart, Fromer, Miller, MacleodEdinburgh University, Kanematsu Laboratories, Columbia UniversityDNA methylation, Epigenetics
Jan 1985NIH publishes its first draft guidelines for proposing experiments in human somatic cell gene theray  Gene therapy
Mar 1985Mullis and Cetus Corporation filed patent for the PCR techniqueMullisCetus CorporationPCR, DNA Sequencing
Mar 1985DNA fingerprinting principle laid outJeffreysUniversity of LeicesterDNA Sequencing
31 Aug 1985Frank Macfarlane Burnet diedBurnettWalter and Eliza Hall InstituteImmunology
07 Sep 1985Rodney R Porter diedPorterOxford UniversityAntibodies
08 Sep 1985John F Enders diedEndersChildren's Hospital BostonVirology, Vaccine
19 Sep 1985Technique published for the accurate insertion of a corrective DNA in the human genomeSmithies, Gregg, Boggs, Koralewski, KucherlapatiUniversity of WisconsinGene eding, Gene Therapy
25 Sep 1985William Cumming Rose diedRoseUniversity of IllinoisNutrition, Biochemistry
25 Sep 1985William Cumming Rose was born Greenville, South Carolina, USARoseUniversity of IllinoisNutrition, Biochemistry
Dec 1985Cetus Corporation and Perkin-Elmer partnered to develop instruments and reagents for PCR Cetus CorporationPCR
Dec 1985Experiments with plasmids indicate double-strand break technique efficient for gene editing in mammalian cellsJasin, de Villiers, Weber, SchaffnerUniversity of ZurichGene editing
Dec 1985IL-2 based immunotherapy shown to reduce tumours in patients with melanoma and renal cell cancerRosenbergNational Cancer InstituteImmunology, Immunotherapy, Oncology
Dec 1985New transgenic mouse model developed to study cancer, opening up the possibility of studying oncogene cooperation and the efficacy of novel anti-cell signal drugs for lymphoma therapyAdams, Harris, Pinkert, Corcoran, Alexander, Cory, Palmiter, BrinsterWalter and Eliza Hall Institute, University of Pennsylvania, Howard Hughes Medical InstituteTrangenic animals, Oncology
20 Dec 1985The Polymerase Chain Reaction technique was publishedMullisCetus CorporationPCR, DNA Sequencing

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