This website provides a curated collection of resources about the people, places and technologies that have enabled biotechnology to transform our healthcare and the world we live in today

Timeline of key events

Timeline of key events in biotechnology

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Date Event People Places Sciences
02 Oct 1987Peter Medawar diedMedawarUniversity College LondonImmunology
06 Nov 1987Publication of gene targeting technique for targetting mutations in any geneThomas, CapecchiUniversity of UtahGene editing, Transgenic animals
Nov 1987First evidence provided for the interaction between the surface molecule CD4 and major histocompatibility class IIDoyle, StromingerHarvard UniversityImmunology, Immunotherapy, Oncology
Dec 1987Discovery of CRISPR mechanismAmemura, Ishino, Makino, Nakata, Shinagawa, Takase, WachiOsaka UniversityCRISPR-Cas9, Gene editing
02 Dec 1987Luis F Leloir diedLeloirInstitute for Biochemical ResearchBiochemistry
1988First reported clinical use of umbilical cord bloodBroxmeyerIndiana UniversityStem cells
1988Campath-1H is created - the first clinically useful humanised monoclonal antibody.Winter, Waldmann, Reichmann, ClarkCambridge University, Laboratory of Molecular BiologyMonoclonal antibodies, Recombinant DNA, Campath
1988Patent application filed for a method to create transgenic mice for the production of human antibodiesBruggeman, Caskey, Neuberger, Surani, Teale, Waldmann, WilliamsLaboratory of Molecular Biology, Babraham Institute, Cambridge UniversityMonoclonal antibodies, gene cloning, transgenic animals
1988US Congress funds genome sequencing  Sequencing DNA, Genomics
21 Mar 1988Patrick Steptoe diedSteptoe Reproduction
Apr 1988Development of first rapid search computer programme to identify genes in a new sequencePearson, Lipman Sequencing DNA, Genomics
Apr 1988OncoMouse patent grantedLeder, StewartHarvard UniversityTransgenic animals
May 1988 - October 1989Cytotoxic T lymphocytes shown to recognise distinct surface markers on human melanomaWolfel, Knuth, Degiovanni, Van den Eynde, Hainaut, BoonLudwig Institute for Cancer ResearchImmunology, Immunotherapy, Oncology
Jul 1988Biochemical initiators of T Cell activitation, CD4 and CD8-p56, discoveredRudd, Trevillyan, Dasupta, Wong, SchlossmanDana-Faber Cancer Institute, Harvard University, Tech UniversityImmunology, Immunotherapy, Oncology
01 Jul 1988The first hematopoietic stem cells were isolated in miceSpangrude, Heimfeld, WeissmanStanford UniversityStem cells
1988 - 1989First evidence discovered of a physical link between oncoproteins and tumour suppressors  Immunology, Immunotherapy, Oncology
Nov 1988Patent application filed for the the use of PCR to create a library of antibody fragmentsGussow, Jones, Olandi, WinterLaboratory of Molecular Biology, Istituto Nazionale dei TumoriMonoclonal antibodies, PCR
Nov 1988Gene targeting technique shown to be efficient in modifying DNA in mammalian cells which can be adapted for other systems. This is the first time genome modification appears possible. Jasin, BergStanford UniversityGene editing
Nov 1988Oncogene disrupted in mice using gene targeting technologyMansour, Thomas, CapecchiUniversity of UtahGene editing
Dec 1988Scientists report cloning the gene for the human cytotoxic T lymphocyte-associated antigen (CTLA-4)Dariavach, Mattei, Golstein, LefrancINSERM-CNRSImmunology, Immunotherapy, Oncology

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