This website provides a curated collection of resources about the people, places and technologies that have enabled biotechnology to transform our healthcare and the world we live in today

Timeline of key events

Timeline of key events in biotechnology

To search for particular terms in the description of the event enter the term in the box below 'Event' on the table and press 'enter'. Alternatively use the dropdown lists to filter by Person, Place or Science. Click here to clear the filter.

Date Event People Places Sciences
1992Mice genetically modified to be deficient in p53 shown to be prone to cancerDonehower, Harvey, Slagle, McArthur, Montgomery, Butel, BradleyBaylor CollegeOncology, p53
1992p53 shown to maintain genome stabilityLivingstone, White, Sprouse, Livanos, Jacks, Tlsty, Yin, Tainsky, Bischoff, Strong, WahlUniversity of North Carolina, MD Anderson Cancer Centrep53
Feb 1992Market interest in monoclonal antibody drugs plummeted with news that the FDA needed more information before it would approve Centoxin CentocorMonoclonal antibodies
21 Mar 1992John C Sheehan diedSheehanMassachusetts Institute of TechnologyAntibacterial agents
10 Apr 1992Peter D Mitchell diedMitchellGlynn Research LaboratoriesBiochemistry
18 Apr 1992Daniel Bovet diedBovetIstituto Superiore di Sanita Pharmacology
02 Sep 1992Barbara McClintock diedMcClintockUniversity of MissouriGenetics
Nov 1992PD-1 (programmed cell death protein 1) discovered by team led by Tasuku HonjoHonjoKyoto UniversityImmune checkpoint inhibitors
1993Embryonic stem cells are proven to be pluripotent; having the ability to differentiate into different cell types  Stem cells
1993Wistar Institute patented Bcl-2, the first of a family of genes associated with different types of cancer Wistar InstituteOncology
Feb 1993Centoxin withdrawn from European market CentocorMonoclonal antibodies
11 Feb 1993Robert W Holley diedHolleyCornell UniversityGenetics
15 Apr 1993Immune molecule, granulocyte-macrophage colony stimulating factor or GM-CSF, discovered to strengthen immunity against tumours Dranoff, Jaffee, Lazenby, Golumbek, Levitsky, Brose, Jackson, Hamada, Pardoll, MulliganMassachusetts Institute of TechnologyImmunology, Immunotherapy, Oncology
Sep 1993p21 shown to be a p53 target geneel-Deiry, Tokino, Velculescu, Levy, Parsons, Trent, Lin, Mercer, Kinzler, Vogelstein Johns Hopkins University, National Center for Human Genome Research, Thomas Jefferson UniversityOncology, p53
Oct 1993Cetus Corporation was sold to Chiron and its patent rights sold for US$300 million to Hoffman-La Roche Cetus Corporation, Chiron, Hoffman-La RochePCR
Oct 1993FDA lays out regulations governing gene therapy  Gene therapy
01 Nov 1993Severo Ochoa diedOchoaNew York UniversityGenetics, DNA
Dec 1993Recombinant human deoxyribonuclease approved by FDA for cystic fibrosis GenentechRecombinant DNA
1994First separation of cancer stem cells from the majority of cells in a cancer   Stem cells
1994Patients with damaged corneas successfully treated with corneal stem cells   Stem cells

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