This website provides a curated collection of resources about the people, places and technologies that have enabled biotechnology to transform our healthcare and the world we live in today

Timeline of key events

Timeline of key events in biotechnology

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Date Event People Places Sciences
23 Aug 1997John C Kendrew diedKendrewLaboratory of Molecular BiologyBiochemistry
Dec 1997First humanised monoclonal antibody approved for marketQueenProtein Design Labs, RocheMonoclonal antibodies, Recombinant DNA
1998Human brain demonstrated to contain cells with stem-like propertiesEriksson, GageSahlgrenska University Hospital, Salk InstituteStem cells
1998FDA approved Trastuzumab (Herceptin) for the treatment of metastatic breast cancer   Monoclonal antibodies, Oncology
Feb 1998Double stranded RNA demonstrated to be potent mechanism for silencing genesFire, Mello, Xu, Montgomery, Kostas, Driver, Carnegie Institution of Washington, Johns Hopkins University, University of Massachusetts Cancer CenterRNA interference
27 Feb 1998George H Hitchings diedHitchingsWellcome Research LaboratoriesPharmacology
May 1998Commercial Human Genome Project launchedVenterCelera GenomicsSequencing DNA,, Genomics
07 May 1998Allan M Cormack diedCormackTufts UniversityDiagnostic imaging
Aug 1998FDA and European regulatory authorities approved the first monoclonal antibody drug for an autoimmune diseaseVilcek, Le, Feldmann, MainiNew York University, Centocor, Kennedy Institute of RheumatologyMonoclonal antibodies
Oct 1998First human embryonic stem cell line derived Thomson, Itskovitz-Eldor, Shapiro, Waknitz, Swiergiel, Marshall, JonesUniversity of Wisconsin-MadisonStem cells
07 Dec 1998Martin Rodbell diedRodbellNational Institute of Environmental Health SciencesCell
Dec 1998Complete genome sequence of the first multicellular organism, the nematode worm Caenorhabditis elegans, is published Sanger Institute, Washington UniversitySequencing DNA, Genomics
20 Dec 1998Alan Lloyd Hodgkin diedHodgkinCambridge UniversityNeuroscience
1999First human chromosome sequence published  Sequencing DNA, Genomics
1999Adult neural stem cells identified as capable of forming new neural stem cellsFrisenKarolinska InstitutetStem cells
1999Discovery of small interfering RNA (siRNA), very small stretches of double-stranded RNA, interfere with genesBaulcombe, Hamilton John Innes CentreRNA interference
21 Feb 1999Gertrude B Elion diedElionWellcome Research LaboratoriesPharmacology
10 Apr 1999Heinz Ludwig Fraenkel-Conrat diedFraenkel-Conrat University of California BerkeleyGenetics, Virology
Jul 1999Disposable bioreactor developed Schering-Plough 
16 Nov 1999Daniel Nathans diedNathans Johns Hopkins University Restriction enzymes, Recombinant DNA

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