This website provides a curated collection of resources about the people, places and technologies that have enabled biotechnology to transform our healthcare and the world we live in today

Timeline of key events

Timeline of key events in biotechnology

To search for particular terms in the description of the event enter the term in the box below 'Event' on the table and press 'enter'. Alternatively use the dropdown lists to filter by Person, Place or Science. Click here to clear the filter.

Date Event People Places Sciences
2003First human trial of gene therapy using modified lentivirus as a vector  Gene therapy
Jan 2003Rare human breast cancer stem cells identified Al-Hajj Stem cells
14 Feb 2003Dolly the sheep, the first cloned mammal diedWilmutRoslin InstituteStem cells, Cloning, Transgenic animals
2003Genetic switch identified that controls the development of T cells, an important immune cell that controls against autoimmunity and excess inflammationFontenot, Gavin, RudenskyHoward Hughes Medical Institute, University of WashingtonImmunology, Immunotherapy
Apr 2003The sequence of the first human genome was published  Sequencing DNA, Genomics
20 Apr 2003Bernard Katz diedKatzUniversity College LondonNeuroscience
22 Apr 2003Stem cells sourced from baby teeth  Stem cells
02 May 2003Publication of successful use of zinc finger enzymes to correct genes in Drosophila (fruit fly).Bibikova, Beumer, Trautman, CarrollUniversity of UtahGene editing, Zinc fingers
02 May 2003Zinc finger method shown to be effective for gene targeting in mammalian somatic cellsPorteus, BaltimoreCalifornia Institute of TechnologyGene editing, Zinc fingers
13 Jun 2003Robert A Good diedGood University of MinnesotaImmunology, Transplantation
04 Aug 2003Frederick Chapman Robbins diedRobbinsWestern Reserve UniversityVirology
Oct 2003China approved the world's first commercial gene therapy to deliver the p53 gene, via an adenovirus vector, to treat squamous cell head and neck cancer.  Gene therapy, p53
2004First derivation of dopaminergic cells from human embryonic stem cells  Stem cells
2004International Consortium of Stem Cell Networks (ICSCN) initiated  Stem cells
2004Phase I trial launched with RNAi treatment (Cand5) for wet age-related macular degeneration  RNA interference
2004Experiments in mice demonstrate an immune checkpoint for blocking cancerAlison, KrummelUniversity California BerkeleyImmunology, Immunotherapy, Oncology
05 Jan 2004Merrill W Chase diedChaseRockefeller University 
Apr 2004US FDA approved new imaging agent for detecting difficult to diagnose cases of appendicitis Wistar Institute, Palatin TechnologiesMonoclonal antibodies
May 2004Study published demonstrating feasibility of using insect-derived antimicrobial peptice as drug-delivery vehicle OtvosWistar Institute 
21 Jul 2004Edward B Lewis diedLewisCalifornia Institute of TechnologyGenetics, Embryology

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