This website provides a curated collection of resources about the people, places and technologies that have enabled biotechnology to transform our healthcare and the world we live in today

Timeline of key events

Timeline of key events in biotechnology

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Date Event People Places Sciences
2000First clinical trials launched to test first immune checkpoint inhibitor drug containing a monoclonal antibody against CTLA-4 (ipilimumab, Yervoy®)AllisonMedarex, University of California BerkleyImmune checkpoint inhibitors, Immunology, Immunotherapy, Oncology, Monoclonal antibodies
18 Jan 2000More clustered repeats of DNA identified in other bacteria and archaea, termed Short Regularly Spaced Repeats (SRSR)Mojica, Diez-Villasenor, Soria, Juez University of Alicante, University Miguel HernandezCRISPR, Gene editing
25 Mar 2000Ruth Erica (Leroi) Benesch diedBeneschColumbia UnivesityBiochemistry
Jun 2000Human genome draft sequence announced  DNA Sequencing, Genomics
01 Sep 2000 Experiments show zinc finger nucleases can create double-stranded DNA breaks in cellsSmith, Bibikova, Whitby, Reddy, Chandrasegaran, Carroll Johns Hopkins University, University of Utah, Pondicherry UniversityGene editing, Zinc fingers
Oct 2000PD-1 protein shown to be important mechanism in dampening down the immune responseFreeman, Long, IwaiDana-Farber Cancer InstituteImmune checkpoint inhibitors
04 Oct 2000Michael Smith died University of British ColumbiaRecombinant DNA, Monoclonal antibodies
15 Oct 2000Konrad Bloch diedBlochHarvard UniversityBiochemistry
Dec 2000First plant DNA sequenced  DNA Sequencing, Genomics
2001The Stem Cell Network is formed   Stem cells
2001Dermal stem cells identified in adult skin tissue   Stem cells
2001Pharmion licenses azacitidine from Pharmacia and Upjohn to Pharmacia's azacityidine technology, patents and clinical data  Epigenetics
Feb 2001First consensus sequence of human genome published CeleraDNA Sequencing
Mar 2001Mechanism uncovered for the way the immune system generates regulatory T-cellsJordanWistar InstituteImmunology
May 2001RNAi demonstrated to be useful genetic toolElbashir, Harborth, Lendecker, Yalcin, Weber, TuschlMax-Planck-Institute for Biophysical ChemistryRNA interference
Aug 2001US places restricitions on embryonic stem cell research  Stem cells
02 Sep 2001Christiaan Barnard diedBarnardUniversity of Cape TownTransplantation
Oct 2001Human embryo cloned to make stem cells Advanced Cell TechnologyStem cells, gene cloning
2002Complete genome sequence of the first mammalian model organism, the mouse, is published   DNA Sequencing
2002International Society for Stem Cell Research (ISCF) established  Stem cells

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