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Timeline of key events

Wistar Institute: Timeline of key events

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Date Event People Places Sciences
1972Wistar Instute named National Cancer Institute - first research institution to gain such a title Wistar InstituteOncology
1975Short-lasting antibodies against influenza virus devisedGerhardWistar InstituteMonoclonal antibodies
Sep 1976Cesar Milstein supplies myeloma cells to Hilary Koprowski at the Wistar Institute for producing monoclonal antibodiesKoprowski, MilsteinLaboratory of Molecular Biology, Wistar InstituteMonoclonal antibodies
Jun 1977First US patent application filed for monoclonal antibodiesCroce, Koprowski, MilsteinWistar InstituteMonoclonal antibodies
May 1979Centocor foundedKoprowski, Schoemaker, WallWistar InstituteMonoclonal antibodies
Oct 1979First US patent for monoclonal antibodies grantedKoprowski, MilsteinWistar InstituteMonoclonal antibodies
1980US licensed first rabies vaccine for human useKoprowski, Plotkin, WiktorWistar InstituteVaccine, Virology
Dec 1980Clinical tials begin with a monoclonal antibody for the treatment of gastrointestinal cancerKoprowskiWistar InstituteMonoclonal antibodies
Sep 1989Giorgio Trinchieri and colleagues identified interleukin-12 (IL-12), a cytokine that helps regulate the body’s resistance to infections and cancerKobayashi, Fitz, Ryan, Hewick, Clark, Chan, Loudon, Sherman, Perussia, TrinchieriWistar InstituteImmunology, Immunotherapy, Oncology
1993Wistar Institute patented Bcl-2, the first of a family of genes associated with different types of cancer Wistar InstituteOncology
1995First monoclonal antibody therapeutic for cancer approved for marketKoprowskiWistar Institute, CentocorMonoclonal antibodies
1995US licensed first wildlife rabies vaccine Wistar InstituteVaccine, Virology
Mar 2001Mechanism uncovered for the way the immune system generates regulatory T-cellsJordanWistar InstituteImmunology
Apr 2002Identification of new enzyme for silencing certain genes, opening new avenues for cancer treatmentsRauscherWistar InstituteGenetics
07 Aug 2002Scientists identified segment of insect-derived antimicrobial peptide called pyrrhocoricin necessary for killing off bacteria opening up possible avenue for developing new antibioticsOtvosWistar InstituteAntimicrobial resistance
20 Aug 2002Link identified between genes responsible for neurofibromatosis, a common neurological disorder, and a protein thought to play role in Alzheimer's diseaseShiekhattarWistar InstituteNeuroscience, Genetics
14 Sep 2002Regulatory T cells discovered to restrain cytolytic T cells attacking cancer via messanger chemical called TGF-betaHerlyn, SomasundaramWistar InstituteImmunology, Immunotherapy, Oncology
Apr 2004US FDA approved new imaging agent for detecting difficult to diagnose cases of appendicitis Wistar Institute, Palatin TechnologiesMonoclonal antibodies
May 2004Study published demonstrating feasibility of using insect-derived antimicrobial peptice as drug-delivery vehicle OtvosWistar Institute 
Feb 2005Enzyme Ubp10 demonstrated to protect the genome from potential destabilising molecular eventsBerger, EmreWistar InstituteDNA, Genetics

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