Genetics: Timeline of key events

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A New Zealand biophysicist, Wikins helped develop x-ray diffraction techniques to determine the structure of DNA. 2004-10-05T00:00:00+0000Study conducted by team led by Shelley Berger published in Molecular Cell.2005-02-17T00:00:00+0000Drug made by MGI Pharma. approved for treatment of myelodysplastic syndromes, bone marrow disorders2006-01-01T00:00:00+0000Drug made by Merck & Co2006-10-06T00:00:00+0000Lederberg was a major pioneer of bacterial genetics. She discovered the lambda phage and invented the replica plating technique. 2006-11-11T00:00:00+0000Kornberg shared the 1959 Nobel Prize for Medicine for the discovery of the 'mechanisms in the biological synthesis of ribonucleic acid and deoxyribonucleic acid.'2007-10-26T00:00:00+0000Achieved by Emmanuel Skordalakes2008-01-01T00:00:00+0000Lederberg shared the 1958 Nobel Prize for Medicine for 'discoveries concerning genetic recombination and the organization of the genetic material of bacteria.'2008-02-02T00:00:00+00002009-11-01T00:00:00+0000Nirenberg shared the 1968 Nobel Prize for Medicine for interpreting the genetic code and its function of protein synthesis.2010-01-15T00:00:00+0000Khorana shared the 1968 Nobel Prize for Medicine for 'interpretation of the genetic code and its function in protein synthesis.'2011-11-09T00:00:00+0000Zinder discovered how hereditary information is transferred from one organism to another. The process is known as genetic transduction.2012-02-03T00:00:00+0000Dulbecco shared the 1975 Nobel Prize for Medicine for 'discoveries concerning the interaction between tumour viruses and the genetic material of the cell.'2012-02-19T00:00:00+00002012-09-28T00:00:00+0000Jacob shared the 1965 Nobel Prize for Medicine for 'discoveries concerning genetic control of enzyme and virus synthesis.' 2013-04-19T00:00:00+00002015-04-01T00:00:00+0000K.B. Chiappinelli, P.L. Strissel, A. Desrichard, et al, 'Inhibiting DNA methylation causes an interferon response in cancer via dsRNA including endogenous retroviruses', Cell, 162 (2015), 974-86.2015-08-27T00:00:00+0000Discovery made as a result of study of 177 members of the Old Order of Amish community in Indiana. S. Khan, et al, 'A null mutation in SERPINE1 protects against biological aging in humans', Science Advances, 3/11 (2017), DOI: 10.1126/sciadv.aao16172017-11-15T00:00:00+0000
Date Event People Places Sciences
5 Oct 2004Maurice H F Wilkins diedWilkinsKing's College LondonDNA, Genetics
Feb 2005Enzyme Ubp10 demonstrated to protect the genome from potential destabilising molecular eventsBerger, EmreWistar InstituteDNA, Genetics
2006FDA approved second DNA methylation inhibitior, decatabine (Dacogen)  DNA methylation, Epigenetics
6 Oct 2006FDA approved first histone deacetylase inhibitor, Vorinostat (Zolinza), for cutaneous T-cell lymphoma  Epigenetics, Oncology
11 Nov 2006Esther Lederberg diedLederbergWisconsin UniversityGenetics, Antimicrobial resistance, Bacteriophages, Lambda phage
26 Oct 2007Arthur Kornberg diedKornbergStanford UniversityGenetics, DNA, RNA
2008Structure of telomerase, an enzyme that conserves the ends of chomosomes, was decoded Wistar InstituteDNA, genetics
2 Feb 2008Joshua Lederberg diedLederbergUniversity of WisconsinGenetics, Plasmids
Nov 2009FDA approved second histone deactylase inhibitor, Romidepsin (Istodax), for cutaneous T-cell lymphoma   Epigenetics, Oncology
15 Jan 2010Marshall W Nirenberg diedNirenbergNational Institutes of HealthGenetics
9 Nov 2011Har Gobind Khorana diedKhoranaConcord, Massachusetts, USAGenetics
3 Feb 2012Norton David Zinder diedZinderRockefeller UniversityGenetics
19 Feb 2012Renato Dulbecco diedDulbeccoImperial Cancer Research Fund LaboratoryGenetics, Virology, Oncology
2012European approval of decatabine (Dacogen) for treatment of acute myeloid leukaemia  Epigenetics, Oncology
19 Apr 2013Francois Jacob diedJacobPasteur InstituteGenetics
Apr 2015Chinese regulatory authorities approved Chidamide, a histone deactylase inhibitor, for peripheral T cell lymphoma  Epigenetics, Oncology
27 Aug 2015Experiments with mice showed that azacytidine treatment enhanced the responsiveness of tumors to anti–CTLA-4 therapy  Cancer immunotherapy, Epigenetics, Immune checkpoint inhibitors, Oncology
15 Nov 2017Rare mutation of gene called Serpine 1 discovered to protect against biological ageing processKhan, Shah, Klyachko, Baldridge, Eren, Place, Aviv, Puterman, Lloyd-Jones, Heiman, Miyata, Gupta, Shapiro, VaughanNorthwestern University, University of British Columbia, New Jersey Medical School, Tohoku University, DNA sequencing, Genetics, Genomics

5 Oct 2004

Maurice H F Wilkins died

Feb 2005

Enzyme Ubp10 demonstrated to protect the genome from potential destabilising molecular events

2006

FDA approved second DNA methylation inhibitior, decatabine (Dacogen)

6 Oct 2006

FDA approved first histone deacetylase inhibitor, Vorinostat (Zolinza), for cutaneous T-cell lymphoma

11 Nov 2006

Esther Lederberg died

26 Oct 2007

Arthur Kornberg died

2008

Structure of telomerase, an enzyme that conserves the ends of chomosomes, was decoded

2 Feb 2008

Joshua Lederberg died

Nov 2009

FDA approved second histone deactylase inhibitor, Romidepsin (Istodax), for cutaneous T-cell lymphoma

15 Jan 2010

Marshall W Nirenberg died

9 Nov 2011

Har Gobind Khorana died

3 Feb 2012

Norton David Zinder died

19 Feb 2012

Renato Dulbecco died

2012

European approval of decatabine (Dacogen) for treatment of acute myeloid leukaemia

19 Apr 2013

Francois Jacob died

Apr 2015

Chinese regulatory authorities approved Chidamide, a histone deactylase inhibitor, for peripheral T cell lymphoma

27 Aug 2015

Experiments with mice showed that azacytidine treatment enhanced the responsiveness of tumors to anti–CTLA-4 therapy

15 Nov 2017

Rare mutation of gene called Serpine 1 discovered to protect against biological ageing process