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Timeline of key events

immunotherapy: Timeline of key events

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Date Event People Places Sciences
08 Feb 1974Immune surveillance theory that immune system provides protection against cancer discredited by research showing that 'Nude' mice lacking immune system function no more likely to develop tumours than normal miceStutmanMemorial Sloan-Kettering Cancer CenterImmunology, Immunotherapy, Oncology
Feb 1975Natural killer cell identified in mice and shown to be important part of immune systemKiessling, Klein, Pross, WigzellKarolinska InstituteImmunology, Immunotherapy, Oncology
15 Apr 1975Human natural killer cell isolatedJondal, ProssKarolinska InstituteImmunology, Immunotherapy, Oncology
24 Apr 1975Discovery of unique molecular marker, idiotype, on blood cancer cells, opening new avenue for cancer diagnosis and therapyStevensonTenovus Research LaboratoryImmunology, Immunotherapy, Oncology
Sep 1975Tumour necrosis factor (TNF) was discovered. It was the first immune molecule shown to kill cancer cellsCarswell, Old, Kassel, Green, Fiore, WilliamsonMemorial Sloan Kettering Cancer CenterImmunology, Immunotherapy, Oncology, Monoclonal antibodies
10 Sep 1976Discovery of first T cell growth factor, later named Interleukin-2 (IL-2)Morgan, Ruscetti, GalloLitton Bioethics Research Laboratories, National Cancer InstituteImmunology, Immunotherapy, Oncology
Feb 1977Scientists find a way to generate T cells in thymic tissue in test tubes, paving the way study mechanisms underlying the regulation of T cell developmentRobinson, OwenUniversity of Newcastle upon TyneImmunology, Immunotherapy, Oncology
01 Apr 1977Development of first anti-idiotype antibodies. These are shown to activate immune defense cells to attack tumour cells in guinea-pigsStevenson, ElliottTenovus Research LaboratoryImmunology, Immunotherapy, Oncology
Jul 1977T cell growth factor, later named Interleukin-2 (IL-2), discovered in mice, providing a means to grow and expand normal lypmphocytes in test tubesRuscetti, Morgan, GalloNational Cancer InstituteImnmunology, Immunotherapy, Oncology
1978T cell-mediated immunity shown to aid tumour regressionBerendt, North, KirsteinTrudeau InstituteImmunotherapy, Oncology
1980US National Cancer Institute added $13.5 million to its budget for new Biological Response Modifiers, igniting search for agents able to modify host's response to tumour cells  Immunotherapy, Oncology
1981First patient successfully treated with anti-idiotype monoclonal antibodyLevyStanford University Medical SchoolImmunotherapy, Monoclonal antibodies
Jun 1982Steven Rosenberg and colleagues first describe lymphokine-activated killer cellsGrimm, Mazumder, Zhang, RosenbergNational Cancer InstituteImmunology, Immunotherapy, Oncology
Nov 1982James Allison and collegues use monoclonal antibody to provide first biochemical description of tumour specific antigen of murine T-lymphomaAllison, McIntyre, BlochUniversity of Texas System Cancer CenterImmunology, Immunotherapy, Monoclonal antibodies, Oncology
01 Dec 1982First molecular markers, antigens, identified in melanoma tumours. These markers are now targeted by cancer drugsHoughton, Eisinger, Albino, Cairncross, OldMemorial Sloan Kettering Cancer CenterImmunology, Immunotherapy, Oncology
24 Mar 1983First cloning of Interleukin 2 (Il-2)Taniguchi, Matsui, Fujita, Takaoka, Kashmina, Yoshimoto, HamuroJapanese Foundation for Cancer Research, Ajinomoto Co IncImmunology, Immunotherapy, Oncology
Nov 1983A team of researchers including Philippa Marrack, John Kappler and James P Allison identified the T cell antigen receptorKappler, Kubo, Haskins, Hannum, Marrack, Pigeon, McIntyre, Allison, TrowbridgeUniversity of Colorado, University of Texas System Cancer Center, National Jewish Hospital and Research Cener, Salk InstituteImmunology, Immunotherapy, Oncology
1984Experiments show that injections with T-cell growth factor interleukin-2 can shrink tumours in humansRosenbergNational Cancer InstituteImmunotherapy
Jun 1984First clinical experiments demonstrate the possibility of training T cells to attack tumoursKnuth, Danowski, Oettgen, OldMemorial Sloan-Kettering Cancer CenterImmunology, Immunotherapy, Oncology
1985T cell surface proteins CD4 and CD8 cloned Maddon, Littman, Godfrey, Maddon Chess, AxelColumbia UniversityImmunology, Immunotherapy, Oncology

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