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Timeline of key events

Cesar Milstein: Timeline of key events

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Date Event People Places Sciences
08 Oct 1927Cesar Milstein was born in Bahia Blanca, ArgentinaMilsteinBahia Blanca, Argentina 
1945 - 1952Cesar Milstein studies for a chemistry degreeMilsteinUniversity of Buenos Aires  
1954 - 1958Cesar Milstein pursues his first doctorate in biochemistryMilstein, StoppaniUniversity of Buenos Aires 
1957The Associacion Quimica Argentina awards Milstein a prize for the best doctoral thesis in chemistry that yearMilsteinUniversity of Buenos Aires 
1957 - 1959Cesar Milstein publishes papers from his doctorate with his supervisor Andres StoppaniMilsteinUniversity of Buenos Aires 
1958 - 1961Cesar Milstein takes up a British Council Scholarship at Cambridge UniversityMilstein, Dixon, WebbSir William Dunn School of Pathology 
1961Cesar Milstein is awarded a second doctorate in biochemistry at Cambridge UniversityMilsteinSir William Dunn School of Pathology 
1961Cesar Milstein takes up a position at the Instituto Malbran, Buenos AiresMilsteinInstituto Malbran 
1962An Argentinian military coup throws Cesar Milstein's academic work into disarrayMilsteinInstituto Malbran 
1963Cesar Milstein returns to Cambridge and begins researching the structure and diversity of antibodiesMilstein, SangerLaboratory of Molecular BiologyMonoclonal antibodies
1964Cesar Milstein publishes his first paper on antibodiesMilsteinLaboratory of Molecular BiologyAntibodies
Jul 1966Cesar Milstein and Sydney Brenner publish theory attributing antibody diversity to somatic mutationBrenner, MilsteinLaboratory of Molecular BiologyAntibodies
Jul 1970Cesar Milstein launches experiments to determine whether somatic mutation underlies antibody diversityCotton, Milstein, SecherLaboratory of Molecular BiologyAntibodies
1973Cesar Milstein meets Georges Kohler at the Basel Institute of ImmunologyKohler, MilsteinBasel Institute of ImmunologyAntibodies
Jul 1973Cesar Milstein and Dick Cotton report the successful fusion of two different myeloma cell lines, one from a mouse and the other from a ratCotton, MilsteinLaboratory of Molecular BiologyMonoclonal antibodies
Jun 1974Georges Kohler joins Cesar Milstein's research team to investigate somatic mutation and antibody diversityKohler, MilsteinLaboratory of Molecular BiologyMonoclonal antibodies
Jan 1975Unlimited long-surviving monoclonal antibodies createdMilstein, KohlerLaboratory of Molecular BiologyMonoclonal antibodies
1975 - 1979First monoclonal antibody created to target a neurotransmitter peptideMilstein, CuelloLaboratory of Molecular Biology, MRC Neurochemical Pharmacology Unit, Oxford UniversityMonoclonal antibodies
Aug 1975First step taken to patent Kohler and Milstein's monoclonal antibodiesMilsteinLaboratory of Molecular BiologyMonoclonal antibodies
07 Aug 1975Cesar Milstein and Georges Kohler publish a paper outlining a technique for producing limitless monoclonal antibodiesKohler, MilsteinLaboratory of Molecular BiologyMonoclonal antibodies

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