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Timeline of key events

immunotherapy: Timeline of key events

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Date Event People Places Sciences
May 1893First successful treatment of cancer patient with immunotherapyColeyMemorial Sloan Kettering Cancer CenterImmunotherapy, Oncology
1895Humans treated with antiserum prepared against human cancer. This established the principle of using serotherapy to fight cancerHericourt, RichetCollege de FranceImmunology, Immunotherapy, Oncology, Monoclonal antibodies
1899First commercial vaccine developed for treatment of sarcomaColeyMemorial Sloan Kettering Cancer Center, Parke Davis & CoImmunology, Immunotherapy, Oncology,
1901 - 1903First successful transplants of tumours in animals reported, providing a new experimental system for studying the role of the immune system in cancerLeob, JensenUniversity of Pennsylvania, Agriculture and Veterinary InstituteImmunotherapy, Oncology
1902First attempt to vaccinate against cancer with a patient's own tumour tissuevon Leyden, Blumenthal Immunology, Immunotherapy, Oncology
1908Paul Ehrlich reports that spontaneously developed tumours can be suppressed by the immune system EhrlichGoettingen UniversityImmunotherapy
1910Austrian physicians Ernest Freund and Gisa Kaminer observed that something in blood serum from cancer patients pervents the destruction of cancer cellsFreund, KaminerRudolf-Stiftung HospitalImmune checkpoint inhibitors, Immunotherapy, Oncology
1914Experiments by James B Murphy demonstrate that lymphocytes help animals reject grafted tumoursMurphyRockefeller IntituteImmunology, Immunotherapy, Oncology
1915 James B Murphy puts forward hypothesis that the nonspecific stimulation of lymphocytes could provide a cure for cancer based on experiments he and John J Morton carried out on miceMurphy, MortonRockefeller InstituteImmunology, Immunotherapy, Oncology
1916 - 1922Disappointing results reported from clinical trials treating breast cancer patients with low doses of X-ray radiation following tumour removal, discrediting the theory that stimulation of lymphocytes could help cure cancer. MurphyRockefeller InstituteImmunology, Immunotherapy, Oncology
1924Austrian physicians Ernest Freund and Gisa Kaminer discover a substance in intestines of cancer patients that reduce ability of normal serum to dissolve cancer cells. Freund, KaminerRudolf-Stiftung HospitalImmune checkpoint inhibitors, Immunotherapy, Oncology
1929First molecular marker, antigen, identified on a tumour, laying foundation for use of antibodies to diagnose and treat cancerWitebsky University of HeidelbergImmunology, Immunotherapy, Oncology, Monoclonal antibodies
Apr 1929Autopsies carried out on tuberculosis patients show them less likely to have contracted cancerPearlJohns Hopkins UniversityImmunology, Immunotherapy, Oncology,
1957 - 1959Concept developed that the immune system naturally protects against cancerBurnet, Lewis Immunotherapy, Oncology
25 Jul 1959Mice injected with BCG vaccine shown to develop resistance to growth of implanted tumours. This was the first direct evidence of the immune system's ability to prevent cancer. Old, Clarke, BenacerrafMemorial Sloan Kettering Cancer CenterImmunotherapy, Oncology
Dec 1966Scientists detect antibodies to the Epstein-Barr virus in patients with nasopharyngeal cancer which suggest the cancer is caused by a virus. Old, Boyse, OettgenMemorial Sloan Kettering Cancer CenterImmunotherapy, Oncology, Virology
Feb 1969Team led by Karl and Ingegerd Hellstrom observe serum from mice with chemically induced tumours can block reaction of lymphocytesHellstrom, Evans, Heppner, Pierce, Yang Fred Hutchinson Cancer CenterImmune checkpoint inhibitors, Immunotherapy, Oncology
Jun 1971Hellstom team suggest that antibodies bound to tumour cells mask their detection by the immune system Sjogren, Hellstrom, BansalFred Hutchinson Cancer CenterImmune checkpoint inhibitors, Immunotherapy, Oncology
1972US National Cancer Institute recommended creation of international registry of immunotherapy trials  Immunotherapy, Oncology
1973First successful bone marrow transplant from unrelated donorGood, O'ReillyMemorial Sloan Kettering Cancer CenterImmunotherapy, Stem, cells, Transplantation, Oncology

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