Timeline of key events in biotechnology

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A Chinese medicine doctor, Ge Hong, described the use of 'yellow soup', a human faecal suspension, administered orally, to treat patients suffering from food poisoning and severe diarrohea. He published this in his book 'Handbook of Prescriptions for Aid First'. 0340-01-01T00:00:00+0000A physician in Verona, Fracastoro put forward his idea in his volumes De Contagione et Contagiosis Morbis (On Contagion and Contagious Diseases). 1546-01-01T00:00:00+0000The tubes were described by Garbielle Falloppio, an anatomist and physician, based on his study of reproductive organs in both sexes. 1561-01-01T00:00:00+0000Francis Bacon was a philosopher who is known as the father of the scientific method. He argued that scientific knowledge should be built upon careful observation of events in nature and the process of induction. His approach to scientific enquiry was published in his book Novum Organum in 1620. Bacon also served as the Attorney General and Lord Chancellor of England under Queen Elizabeth 1. 1561-01-22T00:00:00+0000Gabriele Falloppio described the Fallopian tubes appearing like a trumpet. 1566-01-01T00:00:00+0000An Italian surgeon, Fabricius ab Aquapendente (1537-1619), coined the term 'transfaunation', the transfer of gastrointestinal content from a healthy to a sick animal.1570-01-01T00:00:00+0000Li Shizhen, a Chinese doctor, described a variety of faeces-derived prescriptions, 'yellow soup', for treating abdominal diseases with severe diarrohea, fever, vomiting, and constipation in the most-known book of traditional Chinese medicine, 'Ben Cao Gang Mu' (Compendium of Materia Medica). 1578-01-01T00:00:00+0000Harvey was the first physician to describe in detail the pump action of the heart and the circulation of blood. He published this work in 1628. His findings sparked controversy at the time because they challenged Galen's teachings that blood passed between ventricles through invisible pores and the traditional view that blood circulation involved two separate systems. 1578-04-01T00:00:00+00001600-01-01T00:00:00+0000Francis Bacon was an English philosopher who is known as the father of the scientific method. He argued that scientific knowledge should be built upon careful observation of events in nature and the process of induction. His approach to scientific enquiry was published in his book Novum Organum in 1620. Bacon also served as the Attorney General and Lord Chancellor of England under Queen Elizabeth 1.1626-04-09T00:00:00+0000Leeuwenhoek was a businessman and scientist who is best known for his pioneering work in microscopy. Using microscopes he crafted himself he made the first observations of microorganisms, which he originally called animalcules based on the Latin word 'animalculum' which means tiny animal. He was the first to describe muscle fibres, bacteria, spermatozoa and blood flow in capillaries. 1632-10-24T00:00:00+0000Hooke was a natural philosopher. In 1665 he coined the word 'cell' to describe a basic unit of life in his book, Microphia, describing his observations with microscopes and telescopes and biological experiments. This emerged out of his studies of a thin cutting of cork which he noted to have empty spaces contained by walls, and plants in which he said the cells resembled that of a honeycomb. He calculated that the number of cells in a cubic inch was 1,259,712,000. While Hooke did not grasp the full meaning of his discovery, his work laid the foundation for the cell theory. 1635-07-28T00:00:00+0000The suggestion was made by the English physician William Harvey in his book Exercitationes de generatione animalium (On Animal Generation). He put forward his idea based on his observations with hens' eggs. 1651-01-01T00:00:00+0000Fuller was a physician who practised in Sevenoaks, Kent. Long before the discovery of microbes, Fuller recognised that diseases like measles and smallpox were caused by the 'venom' of a particular organism. He was also one of the first to recognise the specificness of an infection and immunity. Fuller collected and published the best medicines in his Pharmacopoiea, which appeared in at least 12 editions. He was also an early advocate of smallpox inoculation. 1654-06-24T00:00:00+0000Harvey was an English physician. He was the first physician to describe in detail the pump action of the heart and the circulation of blood. He published this work in 1628. His findings sparked controversy at the time because they challenged Galen's teachings that blood passed between ventricles through invisible pores and the traditional view that blood circulation involved two separate systems. 1657-06-03T00:00:00+0000The English physicist Robert Hooke provided the first description of cells to the Royal Society.1663-01-01T00:00:00+0000Jan Swammerdam, a Dutch biologist and microscopist, submitted illustrations of the uterus and ovary to the Royal Society. 1671-01-01T00:00:00+0000The work was done by Reinier de Graaf, a Dutch physician and anatomist1672-01-01T00:00:00+0000van Leeuwenhoek developed the microscope to study the quality of thread in fabrics sold in his draper's shop.1674-01-01T00:00:00+0000This was made by by Antoine van Leeuwenhoek, a Dutch textile merchant, while examining water closely. His letter announcing the discovery was greeted with scepticism by the Royal Society. 1675-01-01T00:00:00+0000
Date Event People Places Sciences
0340First record of the application of faecal microbiota transplant (FMT)Faecal microbiota transplant
1546Girolamo Fracastoro described 'seed-like entities' could spread diseaseFracastoro Germ theory
1561Fallopian tubes described for first timeFallopioUniversity of PaduaReproduction
22 Jan 1561Francis Bacon was born in LondonBacon  
1566Fallopian tubes discovered to extend from the uterus to the ovariesFallopioUniversity of PaduaReproduction
1570 - 1619First application of FMT in animalsAquapendenteFaecal microbiota transplant
1578FMT described for the treatment of abdominal diseasesFaecal microbiota transplant
1 Apr 1578William Harvey was born in Folkestone, United KingdomHarvey Cardiovascular
1600 - 1900Outbreaks of jaundice common in urban populations and armies during wars  Infectious diseases
9 Apr 1626Francis Bacon diedBacon  
24 Oct 1632Antonie van Leeuwenhoek was born in Delft, NetherlandsLeeuwenhoek Microscopy
28 Jul 1635Robert Hooke was born Freshwater, Isle of WightHooke Cell
1651First time idea put forward that all organisms start life in an eggHarvey Reproduction
24 Jun 1654Thomas Fuller was born in Rosehill, Sussex, UKFuller Immunology, Vaccine
3 Jun 1657William Harvey diedHarvey Cardiovascular
1663First time the cell described as a basic unit of lifeHookeRoyal SocietyCell
1671First description of the uterus and ovariesSwammerdam Reproduction
1672First time Fallopian tubes shown to carry products of the ovary to the uterusde Graaf Reproduction
1674Invention of the microscope by Antonie van LeeuwenhoekLeeuwenhoek  
1675First microscopic observations of protozoa and bacteria Leeuwenhoek Bacteriology, Microbiology

0340

First record of the application of faecal microbiota transplant (FMT)

1546

Girolamo Fracastoro described 'seed-like entities' could spread disease

1561

Fallopian tubes described for first time

22 Jan 1561

Francis Bacon was born in London

1566

Fallopian tubes discovered to extend from the uterus to the ovaries

1570 - 1619

First application of FMT in animals

1578

FMT described for the treatment of abdominal diseases

1 Apr 1578

William Harvey was born in Folkestone, United Kingdom

1600 - 1900

Outbreaks of jaundice common in urban populations and armies during wars

9 Apr 1626

Francis Bacon died

24 Oct 1632

Antonie van Leeuwenhoek was born in Delft, Netherlands

28 Jul 1635

Robert Hooke was born Freshwater, Isle of Wight

1651

First time idea put forward that all organisms start life in an egg

24 Jun 1654

Thomas Fuller was born in Rosehill, Sussex, UK

3 Jun 1657

William Harvey died

1663

First time the cell described as a basic unit of life

1671

First description of the uterus and ovaries

1672

First time Fallopian tubes shown to carry products of the ovary to the uterus

1674

Invention of the microscope by Antonie van Leeuwenhoek

1675

First microscopic observations of protozoa and bacteria

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