Donall Thomas: Timeline of key events

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Hodgkin was a prominent pathologist who in 1932 provided the first description of Hodgkin's disease, a form of cancer that originates from the a specific type of white blood cells in lymphoma. His work opened up the start of the active involvement of pathologists in the clinical diagnosis and management of disease. He also helped to get histology recognised as a discipline. Hodgkin was one of the earliest promoters of preventative medicine. 1798-08-17T00:00:00+0000Hodgkin was a renowned British pathologist who in 1932 provided the first description of Hodgkin's disease, a form of cancer that originates from the a specific type of white blood cells in lymphoma. His work opened up the start of the active involvement of pathologists in the clinical diagnosis and management of disease. He also helped to get histology recognised as a discipline. Hodgkin was one of the earliest promoters of preventative medicine. 1866-04-05T00:00:00+0000Thomas was a physician who was a major pioneer of cell and organ transplantation. He is best known for his development of bone marrow transplants, which became a life-saving treatment for blood cancers. Donnall developed the technique on the back of research carried out in the Manhattan Project which showed that 'factors' released by spleen cells stimulated the recovery of irradiated bone marrow. In 1993 he was awarded the Nobel Prize for Medicine on the basis of this research.1920-03-15T00:00:00+0000SE Luria, TF Anderson, 'The identification and characterization of bacteriophages with the electron microscope', PNAS USA, 28/4 (1942), 127-30.1942-04-01T00:00:00+0000The transplant was carried out by Edward Donall Thomas at the Mary Imogene Basset Hospital in New York, which was affiliated to Cornell University. Thomas gave the treatment to a patient with leukaemia. It involved using high doses of total-body irradiation to wipe out the cancer and then infusing marrow cells from an identical twin. While the transplant was initially successful, the patient died later from a recurrence of leukaemia. The achievement was published in ED Thomas, HL Lochte, WC Lu, JW Ferrebee, 'Intravenous infusion of bone marrow in patients receiving radiation and chemotherapy'. The New England Journal of Medicine, 257 (J.W. (12 September 1957), 491–6.1957-09-12T00:00:00+00001959-01-01T00:00:00+0000Thomas, K R, Folger, K R, Capecchi, M R, 'High frequency targeting of genes to specific sites in the mammalian genome,' Cell, 44 (1986), 419–28. 1986-02-14T00:00:00+0000Capecchi, M, 'Site-directed mutagenesis by gene targeting in mouse embyo-derived stem cells', Cell, 51/3 (1987), 503-12.1987-11-06T00:00:00+0000Mansour, S L, Thomas, K R, Capecchi, M R, 'Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes', Nature, 336 (1988): 348–52.1988-11-01T00:00:00+0000Thomas was a physician who was a major pioneer of cell and organ transplantation. He is best known for his development of bone marrow transplants, which became a life-saving treatment for blood cancers. Donnall developed the technique on the back of research carried out in the Manhattan Project which showed that 'factors' released by spleen cells stimulated the recovery of irradiated bone marrow. In 1990 he was awarded the Nobel Prize for Medicine on the basis of this research.2012-10-20T00:00:00+0000
Date Event People Places Sciences
17 Aug 1798Thomas Hodgkin bornThomas HodgkinSt Thomas's Hospital, Guy's HospitalPathology, Oncology
5 Apr 1866Thomas Hodgkin diedThomas HodgkinSt Thomas's Hospital, Guy's HospitalOncology
15 Mar 1920Edward Donnall Thomas was born in Mart, Texas, USAThomasFred Hutchinson Cancer Research CenterTransplantaion, Immunology
Apr 1942Electron microscope used to identigy and characterise a bacteriophageLuria, Thomas AndersonColumbia UniversityBacteriophages
12 Sep 1957First report of successful bone marrow transplants performed in human patientsThomas, Lochte, Lu, FerrebeeBassett Medical Center, Cornell UniversityStem cells, Transplantation
1959Experiments in mice prove the existence of resident blood stem cells in marrowThomas Bassett Medical CenterStem cells
14 Feb 1986Gene targeting technique used to correct defective gene in the chromosome of a mammalian cellThomas, Folger, CapecchiUniversity of UtahGene editing
6 Nov 1987Publication of gene targeting technique for targetting mutations in any geneThomas, CapecchiUniversity of UtahGene editing, Transgenic animals
Nov 1988Oncogene disrupted in mice using gene targeting technologyMansour, Thomas, CapecchiUniversity of UtahGene editing
20 Oct 2012E Donnall Thomas diedThomasFred Hutchinson Cancer Research CenterTransplantaion, Immunology

17 Aug 1798

Thomas Hodgkin born

5 Apr 1866

Thomas Hodgkin died

15 Mar 1920

Edward Donnall Thomas was born in Mart, Texas, USA

Apr 1942

Electron microscope used to identigy and characterise a bacteriophage

12 Sep 1957

First report of successful bone marrow transplants performed in human patients

1959

Experiments in mice prove the existence of resident blood stem cells in marrow

14 Feb 1986

Gene targeting technique used to correct defective gene in the chromosome of a mammalian cell

6 Nov 1987

Publication of gene targeting technique for targetting mutations in any gene

Nov 1988

Oncogene disrupted in mice using gene targeting technology

20 Oct 2012

E Donnall Thomas died