Cambridge University: Timeline of key events

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The patient received a stem-cell transplant that replaced their white blood cells with HIV-resistant versions. The cells were taken from a donor who had two copies of a mutation in the CCR5 gene that confers resistance to HIV infection. The CCR5 gene codes for a receptor on white blood cells involved in the body's immune response. HIV normally binds to these receptors and attacks the cell. By removing the gene the receptors stop working normally. The patient was given the treatment as part of therapy for blood cancer. He was able to stop taking antiretroviral drugs after 16 months, and 18 months later had no sign of the virus. The research was published in RK Gupta, et al, Nature (2019), DOI 10.1038/s41586-019-1027-42019-03-05T00:00:00+0000
Date Event People Places Sciences
5 Mar 2019Second patient reported free of HIV after receiving stem-cell therapyGuptaUniversity of CambridgeStem cells, Gene therapy

5 Mar 2019

Second patient reported free of HIV after receiving stem-cell therapy

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