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Event |
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Palade was a cell biologist who helped determine cell function and organisation. He and his colleagues demonstrated that all plant cells and some animal and bacteria cells have a vacuole, an enclosed compartment in the cell membrane, which contains enzymes essential to maintaining the cell's health. In 1974 he was awarded the Nobel Prize in Physiology and Medicine for his innovations in electron microscopy and cell fractionation, which laid the foundation for molecular cell biology, and his discovery of the ribosomes of endoplastic reticulum in 1955.
1912-11-19T00:00:00+0000| 19 Nov 1912 | | George E Palade was born in Iasi, RomaniaPalade | Rockefeller University | Cell |
A biochemist, Moore helped develop the first automated amino acid analyser in 1958. The machine transformed the ability to analyse the amino acid sequences of proteins. Together with William H Stein, Moore used the machine to determine the amino acid sequence of the ribonuclease molecule. Moore shared the 1972 Nobel Prize for Chemistry for this work. 1913-09-04T00:00:00+0000| 4 Sep 1913 | | Stanford Moore was born in Chicago IL, USAMoore | Rockefeller University | Biochemistry |
JB Murphy, 'Studies on tissue specificity', Journal of Experimental Medicine, 19 (1914), 181-86.1914-01-01T00:00:00+0000| 1914 | | Experiments by James B Murphy demonstrate that lymphocytes help animals reject grafted tumoursMurphy | Rockefeller Intitute | Immunology, Cancer immunotherapy, Oncology |
The experiments involved increasing the number of lymphocytes in the blood of mice by treating them with low doses of X-rays. JB Murphy, JJ Morton, 'The effects of X-rays on the resistance to cancer in mice', Science, 42 (1915), 842. 1915-01-01T00:00:00+0000| 1915 | | James B Murphy puts forward hypothesis that the nonspecific stimulation of lymphocytes could provide a cure for cancer based on experiments he and John J Morton carried out on miceMurphy, Morton | Rockefeller Institute | Immunology, Cancer immunotherapy, Oncology |
The trials were carried out by James B Murphy and colleagues at the Rockefeller Institute. 1916-01-01T00:00:00+0000| 1916 - 1922 | | Disappointing results reported from clinical trials treating breast cancer patients with low doses of X-ray radiation following tumour removal, discrediting the theory that stimulation of lymphocytes could help cure cancer. Murphy | Rockefeller Institute | Immunology, Cancer immunotherapy, Oncology |
de Duve was a cytologist and biochemist. The son of Belgian refugees who fled to England during World War I, de Duve is associated with the discovery of peroxisome and lysosome in the 1950s and 1960s. They are two specialised subunits found within the cell and are vital to the function of the cell. His work paved the way to unravelling the biology of several genetic diseases. He was awarded the Nobel Prize for Medicine in 1974 on the back of his 'discoveries concerning the structural and functional organisation of the cell.'
de Duve helped determine the structure and function of parts of the cell. 1917-10-02T00:00:00+0000| 2 Oct 1917 | | Christian R de Duve was born in Thames Ditton, UKde Duve | Rockefeller University | Cell |
A geneticist by training, Sager enjoyed two careers. She first made her mark in the 1950s and 1950s when she discovered the transmission of genetic traits through chloroplast DNA. This was the first example of genetics not involving the cell nucleus. Later on, in the early 1970s, she became a major pioneer in cancer genetics. She was one of the first to propose and investigate the function of tumour suppressor genes. 1918-02-07T00:00:00+0000| 7 Feb 1918 | | Ruth Sager was born in Brookline, Massachusetts, USASager | Rockefeller University | Genetics, Oncology |
Daly trained as a biochemist and was the first Black American woman to earn a doctorate in chemistry (from Columbia University, 1947). Her early research looked at the effects of cholesterol on the mechanisms of the heart, the effects sugars and other nutrients on the health of the arteries and the impact of advanced aged and hypertension on the circulatory system. This she did at Rockefeller Institute in New York. She subsequently joined Columbia University where she investigated how proteins are produced and organised in the cell. In addition to her scientific work, Daly was an ardent campaigner for getting minority students into medical school and graduate science programmes. 1921-04-16T00:00:00+0000| 16 Apr 1921 | | Marie M Daly was born in Corona, Queens, NY, USAMary Daly | Rockefeller Institute, Columbia University | Biochemistry, Cardiovascular |
Merrifield was a biochemist and organic chemist. In 1984 he was awarded the Nobel Prize for Chemistry for inventing a process known as solid phase peptide synthesis. He developed the technique in 1965. It provided a methodology for chemical synthesis on a solid matrix. By the mid-1960s he and his team had proved the method could be used to synthesise bradykinin, angiotensin, desamino-oxytocin and insulin. In 1969 they managed to synthesise the enzyme, ribonuclease A. This was the first proof of the chemical nature of enzymes. Merrifield's method is now a rountine method for automatically synthesising large proteins, novel nucleotides, or short fragments of DNA.1921-07-15T00:00:00+0000| 15 Jul 1921 | | Robert Bruce Merrifield born in Fort Worth, Texas, USAMerrifield | Rockefeller Institute | Biochemistry |
Known as the Carrel or T flask, this vessel was developed by Alexis Carrel. The flask had an angled neck to prevent airborne particles from falling into the flask when it was open. The neck could also be sterilised with a flame both before and after adding or removing nutrient broth. 1923-01-01T00:00:00+0000| 1923 | | First specifically designed cell culture vessel Carrel | Rockefeller University | Cell culture |
Loeb was a German-American physiologist and biologist who demonstrated the possibility of reproduction without male fertilisation, parthenogenesis, in sea urchin eggs. He found it was possible to stimulate embryonic development in the eggs of sea urchins without sperm by making slight chemical changes to the water where the eggs were kept. This he discovered while conducting experiments at the Marine Biological Laboratory in Woods Hole, Massachusetts. His results were published in 'Activation of the unfertilized egg by ultra-violet rays', Science, 40/1036 (1914), 680-1. While Loeb was nominated for the Nobel Prize many times he never won.
1924-02-11T00:00:00+0000| 11 Feb 1924 | | Jacques Loeb diedLoeb | Rockefeller University | Reproduction |
Greengard is a neurobiologist who shared the 2000 Nobel Prize for Medicine for his discovery of how the neurotransmitter, dopamine, functions in the nervous system. Beginning this work in the late 1960s, Greengaard showed that dopamine binds to receptors on the outer membrane of a neuron. This stimulates a second messenger, cyclic AMP, which in itself activates an enzyme that adds phosphate molecules to other proteins in the neuron. Greengard's work has paved the way to greater understanding of certain neurological and psychiatric disorders and development of new treatments. 1925-12-11T00:00:00+0000| 11 Dec 1925 | | Paul Greengard was born in New York, USAGreengard | Rockefeller University | Neuroscience |
The vaccine was developed by Alexis Carel with Tom Rivers. It was made from vaccinia, or cowpox virus, collected from calf lymph fluid. The vaccine did not prove successful as it did not provide sufficient protection against smallpox, but it showed a way of developing safer vaccines by growing the virus in tissue culture. The technique was published in A Carrel, TM Rivers, 'La Fabrication du vaccin in vitro', Comptes Rendus Soc Biol, 96 (1927), 848. One of the advantages with the new method was that the vaccine had fewer side effects and did not leave a scar after vaccination. 1927-01-01T00:00:00+0000| 1927 | | First viral vaccine developedCarrel, Rivers | Rockefeller University | Cell culture, Vaccines |
Noguchi was a Japanese bacteriologist. He is best remembered for his identification, in 1913, of the causative agent of syphilis (the bacteria Treponema pallidum), and identification of the pathogen responsible for Carrion's disease (a Leishmania parasite). Unable to get a medical position in Japan because of his hand deformity which potential employers feared would put off potential patients, Noguchi spent his life doing laboratory work in the United States. While valued in his lifetime, his reputation took a battering after his death because researchers struggled to reproduce some of his claims, including having discovered the cause of yellow fever, polio and rabies. 1928-05-21T00:00:00+0000| 21 May 1928 | | Hideyo Noguchi diedNoguchi | Rockefeller Institute | Bacteriology, Infectious diseases |
Zinder was a biologist who discovered how hereditary information is transferred from one organism to another. The process is known as genetic transduction. Carrying out experiments with the bacteria species Salmonella, Zinder discovered that bacteriophages, a type of virus, carry genes from one bacterium to another. He did the work with Joshua Lederberg, his doctoral supervisor. 1928-11-07T00:00:00+0000| 7 Nov 1928 | | Norton D Zinder was born New York City, USAZinder | Rockefeller University | Genetics |
Edelman was a biologist renowned for his research on antibodies. His research helped determine the chemical structure of antibodies in the early 1960s. It showed that antibodies were made up of two light and heavy chains linked together by disulfide bonds. The breakthrough immediately galvanised feverish activity in all fields of immunological science, paving the way to the development of antibodies for both diagnostics and therapy. Edelman was awarded the Nobel Prize for Medicine in 1972 for his work.1929-07-01T00:00:00+0000| 1 Jul 1929 | | Gerald M Edelman was born in New York NY, USAEdelman | Rockefeller University | Antibodies, Immunology |
The term was coined by Warren Weaver to convey the idea of the physical and chemical explanations of life. 1938-01-01T00:00:00+0000| 1938 | | First use of the term 'molecular biology'Weaver | Rockefeller University | |
R Dubos (1942) ‘Microbiology’, Annual Review Biochemistry, 11: 659-78.1939-07-01T00:00:00+0000| Jul 1939 | | Rene Dubos issued warning that bacteria will always develop resistance to antibacterial agentsDubos | Rockefeller Institute for Medical Research | Antimicrobial resistance |
Rene Dubos discovered gramicidin and tyrocidine after feeding specific bacteria particles to soil organisms. 1939-09-09T00:00:00+0000| 9 Sep 1939 | | First antibacterial agents reported using systematic approach, paving way to first commercialised antibioticsDubos | Rockefeller Institute for Medical Research | Antibacterial agents |
Wollstein was a pioneering American paediatric pathologist at a time when women rarely worked in the field of pathology. One of her key contributions was the development of antiserum therapies to treat both paediatric and adult infectious diseases, including a potent polyvalent antiserum to treat meningitis. She was the first woman to ever be elected a member of the American Pediatric Society. In 1904 she joined the Rockefeller Institute for Medical Research where she did important experimental work on polio, pneumonia and other diseases. Her work was important for showing that mumps could be viral in nature.1939-09-30T00:00:00+0000| 30 Sep 1939 | | Martha Wollstein diedWollstein | Rockefeller Institute for Medical Research | Antibodies, Infectious diseases |
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