Wistar Institute: Timeline of key events
Mouseover the event title for a more detailed description of the event (if available). To search for particular terms in the description of the event enter the term in the box below 'Event' on the table and press 'enter'. Alternatively use the dropdown lists to filter by Person, Place or Science. Click here to clear the filter.
Date | Event | People | Places | Sciences |
---|---|---|---|---|
1969 | Splenic fragment technique devised for growing antibodies | Klinman | Wistar Institute | Monoclonal antibodies |
1969 - 1970 | First license approved in US and Europe for vaccine against rubella (German measles) | Plotkin | Wistar Institute | Vaccines, Virology, Infectious diseases |
1972 | Wistar Instute named National Cancer Institute - first research institution to gain such a title | Wistar Institute | Oncology | |
1975 | Short-lasting antibodies against influenza virus devised | Gerhard | Wistar Institute | Monoclonal antibodies |
Sep 1976 | Cesar Milstein supplies myeloma cells to Hilary Koprowski at the Wistar Institute for producing monoclonal antibodies | Koprowski, Milstein | Laboratory of Molecular Biology, Wistar Institute | Monoclonal antibodies |
Jun 1977 | First US patent application filed for monoclonal antibodies | Croce, Koprowski, Milstein | Wistar Institute | Monoclonal antibodies |
May 1979 | Centocor founded | Koprowski, Schoemaker, Wall | Wistar Institute | Monoclonal antibodies |
Oct 1979 | First US patent for monoclonal antibodies granted | Koprowski, Milstein | Wistar Institute | Monoclonal antibodies |
1980 | US licensed first rabies vaccine for human use | Koprowski, Plotkin, Wiktor | Wistar Institute | Vaccines, Virology |
Dec 1980 | Clinical tials begin with a monoclonal antibody for the treatment of gastrointestinal cancer | Koprowski | Wistar Institute | Monoclonal antibodies |
Sep 1989 | Giorgio Trinchieri and colleagues identified interleukin-12 (IL-12), a cytokine that helps regulate the body’s resistance to infections and cancer | Kobayashi, Fitz, Ryan, Hewick, Clark, Chan, Loudon, Sherman, Perussia, Trinchieri | Wistar Institute | Immunology, Cancer immunotherapy, Oncology |
Feb 1992 | Monoclonal antibodies market crashed following FDA's call for more information for Centocor's drug, Centoxin | Schoemaker, Koprowski, Milstein | Centocor, Wistar | Monoclonal antibodies |
1993 | Wistar Institute patented Bcl-2, the first of a family of genes associated with different types of cancer | Wistar Institute | Oncology | |
1995 | First monoclonal antibody therapeutic for cancer approved for market | Koprowski | Wistar Institute, Centocor | Monoclonal antibodies |
1995 | US licensed first wildlife rabies vaccine | Wistar Institute | Vaccine, Virology | |
Mar 2001 | Mechanism uncovered for the way the immune system generates regulatory T-cells | Jordan | Wistar Institute | Immunology |
Apr 2002 | Identification of new enzyme for silencing certain genes, opening new avenues for cancer treatments | Rauscher | Wistar Institute | Genetics |
7 Aug 2002 | Scientists identified segment of insect-derived antimicrobial peptide called pyrrhocoricin necessary for killing off bacteria opening up possible avenue for developing new antibiotics | Otvos | Wistar Institute | Antibacterial agents |
20 Aug 2002 | Link identified between genes responsible for neurofibromatosis, a common neurological disorder, and a protein thought to play role in Alzheimer's disease | Shiekhattar | Wistar Institute | Neuroscience, Genetics |
14 Sep 2002 | Regulatory T cells discovered to restrain cytolytic T cells attacking cancer via messanger chemical called TGF-beta | Herlyn, Somasundaram | Wistar Institute | Immunology, Cancer immunotherapy, Oncology |
1969
Splenic fragment technique devised for growing antibodies
1969 - 1970
First license approved in US and Europe for vaccine against rubella (German measles)
1972
Wistar Instute named National Cancer Institute - first research institution to gain such a title
1975
Short-lasting antibodies against influenza virus devised
Sep 1976
Cesar Milstein supplies myeloma cells to Hilary Koprowski at the Wistar Institute for producing monoclonal antibodies
Jun 1977
First US patent application filed for monoclonal antibodies
May 1979
Centocor founded
Oct 1979
First US patent for monoclonal antibodies granted
1980
US licensed first rabies vaccine for human use
Dec 1980
Clinical tials begin with a monoclonal antibody for the treatment of gastrointestinal cancer
Sep 1989
Giorgio Trinchieri and colleagues identified interleukin-12 (IL-12), a cytokine that helps regulate the body’s resistance to infections and cancer
Feb 1992
Monoclonal antibodies market crashed following FDA's call for more information for Centocor's drug, Centoxin
1993
Wistar Institute patented Bcl-2, the first of a family of genes associated with different types of cancer
1995
First monoclonal antibody therapeutic for cancer approved for market
1995
US licensed first wildlife rabies vaccine
Mar 2001
Mechanism uncovered for the way the immune system generates regulatory T-cells
Apr 2002
Identification of new enzyme for silencing certain genes, opening new avenues for cancer treatments
7 Aug 2002
Scientists identified segment of insect-derived antimicrobial peptide called pyrrhocoricin necessary for killing off bacteria opening up possible avenue for developing new antibiotics
20 Aug 2002
Link identified between genes responsible for neurofibromatosis, a common neurological disorder, and a protein thought to play role in Alzheimer's disease
14 Sep 2002
Regulatory T cells discovered to restrain cytolytic T cells attacking cancer via messanger chemical called TGF-beta
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