Wistar Institute: Timeline of key events

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The diagnostic, called NeutroSpectT, uses a monoclonal antibody, SSEA1, discovered at the Wistar Institute and developed by Palatin Technologies.2004-04-05T00:00:00+0000Research led by Laszlo Otvos published in Molecular Pharmceutics.2004-05-01T00:00:00+0000Study conducted by team led by Shelley Berger published in Molecular Cell.2005-02-17T00:00:00+0000The vaccine RotaTeq took 25 years to develop. It was developed by Stanley Plotkin, H Fred Clark and Paul Offit.2006-01-01T00:00:00+0000Research conducted by collaboration between Wistar Institute and Vienna Biocenter, published in 'Nature'.2006-11-15T00:00:00+0000Research led by Emmanuel Skordalakes published in the journal 'Structure'. 2007-11-13T00:00:00+0000Achieved by Emmanuel Skordalakes2008-01-01T00:00:00+0000Published in 'Nature Medicine', the system deloys glycoprotein D fused with genes from target antigens to increase the immune response. The work was led by Hildegund C.J. Ertl.2008-01-31T00:00:00+0000Klinman was an American immunologist who developed the splenic focus assay, a tool that allowed analysis of antibody production derived from single clones of B cells. He used the tool to analyse immune tolerance and immune responses to influenza. In additon he invented the splenic fragment system, a technique that helped generate some of earliest monoclonal antibodies against viral antigens and cancer.2010-05-04T00:00:00+0000A Polish-born virologist, Koprowski invented the world's first effective live polio vaccine while at Lederle Laboratories. He developed the vaccine by attenuating the virus in brain cells of a cotton rat. In January 1948 he injected the vaccine into himself. The vaccine had the advantage that it directly entered the intestinal tract and provided long-lasting immunity. Within a decade the vaccine had been adopted on four continents. Koprowski went on to become the director of the Wistar Institute where in the 1960s he led efforts to improve the rabies vaccine. He subsequently became the first scientist, together with colleagues, to hold a patent for monoclonal antibodies. Born to Jewish parents, Koprowski was forced to flee Poland in 1939 after Germany invaded the country. 2013-04-11T00:00:00+0000Vaccine developed by David Weiner together with collaborators at Inovio Pharmaceuticals, Inc., GeneOne Life Science, Inc., National Microbiology Laboratory at the Public Health Agency of Canada, and the University of Pennsylvania.2016-06-23T00:00:00+0000Research carried out by a team led by Dimitry I Gabriolvich. 2016-08-05T00:00:00+0000
Date Event People Places Sciences
Apr 2004US FDA approved new imaging agent for detecting difficult to diagnose cases of appendicitis Wistar Institute, Palatin TechnologiesMonoclonal antibodies
May 2004Study published demonstrating feasibility of using insect-derived antimicrobial peptice as drug-delivery vehicle OtvosWistar Institute 
Feb 2005Enzyme Ubp10 demonstrated to protect the genome from potential destabilising molecular eventsBerger, EmreWistar InstituteDNA, Genetics
2006Vaccine approved for preventing rotavirus, a major kiler of children Plotkin, Clark, OffitWistar InstituteVaccines, Virology, Infectious diseases
15 Nov 2006New enzyme identified as suppressor of p53 protein, a key molecule for controlling cancer in humansBergerWistar Institute, Vienna BiocenterOncology, p53
13 Nov 2007Inappropriate activation of telomerase, an enzyme, shown to be associated with uncontrollable proliferation of cells seen in human cancersSkordalakesWistar InstituteOncology
2008Structure of telomerase, an enzyme that conserves the ends of chomosomes, was decoded Wistar InstituteDNA, genetics
31 Jan 2008New vaccine delivery system unveiled for preventing viral diseasesErtlWistar InstituteVaccines, Virology
4 May 2010Norman Klinman died in San Diego, California, USAKlinmanWistar Institute, University of PennsylvaniaAntibodies, Monoclonal antibodies, Immunology
11 Apr 2013Hilary Koprowski diedKoprowskiLederle Laboratories, Wistar InstituteVaccines, Monoclonal antibodies, Infectious diseases
23 Jun 2016FDA approved first clinical trial for zika virus vaccineWeinerWistar Institute, University of Pennsylvania, Inovio Pharmaceuticals, GeneOne Life Science, Public Health Agency of CanadaVaccines, Virology, Infectious diseases
Aug 2016Marker identified for myeloid-derived suppressor cells, a type of cell associated with tumour resistance to certain cancer treatments Wistar InstituteImmunology, Cancer immunotherapy, Oncology

Apr 2004

US FDA approved new imaging agent for detecting difficult to diagnose cases of appendicitis

May 2004

Study published demonstrating feasibility of using insect-derived antimicrobial peptice as drug-delivery vehicle

Feb 2005

Enzyme Ubp10 demonstrated to protect the genome from potential destabilising molecular events

2006

Vaccine approved for preventing rotavirus, a major kiler of children

15 Nov 2006

New enzyme identified as suppressor of p53 protein, a key molecule for controlling cancer in humans

13 Nov 2007

Inappropriate activation of telomerase, an enzyme, shown to be associated with uncontrollable proliferation of cells seen in human cancers

2008

Structure of telomerase, an enzyme that conserves the ends of chomosomes, was decoded

31 Jan 2008

New vaccine delivery system unveiled for preventing viral diseases

4 May 2010

Norman Klinman died in San Diego, California, USA

11 Apr 2013

Hilary Koprowski died

23 Jun 2016

FDA approved first clinical trial for zika virus vaccine

Aug 2016

Marker identified for myeloid-derived suppressor cells, a type of cell associated with tumour resistance to certain cancer treatments

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