CRISPR-Cas9: Timeline of key events
Mouseover the event title for a more detailed description of the event (if available). To search for particular terms in the description of the event enter the term in the box below 'Event' on the table and press 'enter'. Alternatively use the dropdown lists to filter by Person, Place or Science. Click here to clear the filter.
Date | Event | People | Places | Sciences |
---|---|---|---|---|
Dec 1987 | The CRISPR mechanism first published | Amemura, Ishino, Makino, Nakata, Shinagawa, Takase, Wachi | Osaka University | CRISPR-Cas9, Gene editing |
18 Jan 2000 | More clustered repeats of DNA identified in other bacteria and archaea, termed Short Regularly Spaced Repeats (SRSR) | Mojica, Diez-Villasenor, Soria, Juez | University of Alicante, University Miguel Hernandez | CRISPR-Cas9, Gene editing |
Mar 2002 | Term CRISPR-Cas9 published for first time | Mojica, Jansen, Embden, Gaastra, Schouls | Utrecht University | CRISPR-Cas9, Gene editing |
2005 | Jennifer Doudna and Jillian Banfield started investigating CRISPR | Doudna, Banfield | University of California Berkeley | CRISPR-Cas9 |
1 Aug 2005 | French scientists suggested CRISPR spacer sequences can provide cell immunity against phage infection and degrade DNA | Bolotin, Quinquis, Sorokin, Ehrlich | Institut National de la Recherche Agronomique | CRISPR-Cas9, Gene editing |
11 Nov 2005 | American researchers identified new familes of Cas genes which appeared to help in protecting bacteria against invading viruses | Haft, Selengut, Mongodin, Nelson | The Institute for Genomic Research | CRISPR-Cas9, Gene editing |
23 Mar 2007 | Experiments demonstrate for the first time the role of CRISPR together with Cas9 genes in protecting bacteria against viruses | Barrangou, Horvath, Fremaux, Deveau, | Danisco USA Inc | CRISPR-Cas9, Gene editing |
2008 | DNA, not RNA, demonstrated to be the molecular target of most CRISPR-Cas systems | CRISPR-Cas9, Gene editing | ||
Feb 2008 | Scientists coin the term 'protospacer' to denote viral sequence that corresponds to a 'spacer' in the CRISPR-Cas9 system | CRISPR-Cas9, Gene editing | ||
Aug 2008 | Scientists characterised the RNA processing pathway in CRISPR system | Wageningen University, University of Sheffield, National Institutes of Health | CRISPR-Cas9, Gene editing | |
Dec 2008 | Scientists published the RNA gene silencing pathway involved in the CRISPR-Cas mechanism | Carte, Wang, Li, Terns | University of Georgia, Florida State University | CRISPR-Cas9, Gene editing |
2011 | Classification of the CRISPR-Cas system is proposed | CRISPR-Cas9, Gene editing | ||
Mar 2011 | Emmanuelle Charpentier and Jennifer Doudna joined forces to investigate Cas9 enzyme | Doudna, Charpentier, Hinek, Hauser | University of California Berkeley, Umea University | CRISPR-Cas9 |
Apr 2012 | First commercialisation of CRISPR-Cas 9 technology | Dupont | CRISPR-Cas9, Gene editing | |
May 2012 | First patent application submitted for CRISPR-Cas 9 technology | Doudna, Charpentier | University of California Berkeley, University of Vienna | CRISPR-Cas9, Gene editing |
17 Aug 2012 | Publication of radically new gene editing method that harnesses the CRISPR-Cas9 system | Jinek, Chylinski, Fonfara, Hauer, Doudna, Charpentier | University of California Berkeley | CRISPR-Cas9, Gene editing |
25 Sep 2012 | Scientists at the Vilnius University published paper elucidating the potential of CRSIPR/Cas9 to edit DNA | Siksnys, Gasiunas, Barrangou, Horvath | Vilunius University | CRISPR-Cas9, Gene editing, |
12 Dec 2012 | Fast track application for CRISPR-Cas 9 technology submitted to US patent office. | Zhang | Broad Institute, Massachusetts Institute of Technology | CRISPR-Cas9, Gene editing |
Jan 2013 | CRISPR-Cas is used in human genome editing | CRISPR-Cas9, Gene editing | ||
Jan 2013 | CRISPR-Cas is used to edit the genome of a zebrafish | CRISPR-Cas9, Gene editing | ||
Dec 1987
The CRISPR mechanism first published
18 Jan 2000
More clustered repeats of DNA identified in other bacteria and archaea, termed Short Regularly Spaced Repeats (SRSR)
Mar 2002
Term CRISPR-Cas9 published for first time
2005
Jennifer Doudna and Jillian Banfield started investigating CRISPR
1 Aug 2005
French scientists suggested CRISPR spacer sequences can provide cell immunity against phage infection and degrade DNA
11 Nov 2005
American researchers identified new familes of Cas genes which appeared to help in protecting bacteria against invading viruses
23 Mar 2007
Experiments demonstrate for the first time the role of CRISPR together with Cas9 genes in protecting bacteria against viruses
2008
DNA, not RNA, demonstrated to be the molecular target of most CRISPR-Cas systems
Feb 2008
Scientists coin the term 'protospacer' to denote viral sequence that corresponds to a 'spacer' in the CRISPR-Cas9 system
Aug 2008
Scientists characterised the RNA processing pathway in CRISPR system
Dec 2008
Scientists published the RNA gene silencing pathway involved in the CRISPR-Cas mechanism
2011
Classification of the CRISPR-Cas system is proposed
Mar 2011
Emmanuelle Charpentier and Jennifer Doudna joined forces to investigate Cas9 enzyme
Apr 2012
First commercialisation of CRISPR-Cas 9 technology
May 2012
First patent application submitted for CRISPR-Cas 9 technology
17 Aug 2012
Publication of radically new gene editing method that harnesses the CRISPR-Cas9 system
25 Sep 2012
Scientists at the Vilnius University published paper elucidating the potential of CRSIPR/Cas9 to edit DNA
12 Dec 2012
Fast track application for CRISPR-Cas 9 technology submitted to US patent office.
Jan 2013
CRISPR-Cas is used in human genome editing
Jan 2013
CRISPR-Cas is used to edit the genome of a zebrafish
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