Genetics: Timeline of key events

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2012-09-28T00:00:00+0000Ruddle helped pioneer human gene mapping and established many of the techniques and a framework for setting up the Human Genome Project. He also generated, with Jon W. Gordon and George Scango the first successful transgenic mouse. This heralded the development of genetically modified animals as research models to investigate the function of genes and genetic cause of disease. Ruddle also discovered, with William McGinnis, the first human homeobox genes, important regulators of gene development. 2013-03-10T00:00:00+00002015-04-01T00:00:00+0000K.B. Chiappinelli, P.L. Strissel, A. Desrichard, et al, 'Inhibiting DNA methylation causes an interferon response in cancer via dsRNA including endogenous retroviruses', Cell, 162 (2015), 974-86.2015-08-27T00:00:00+0000Griffin was a leading expert on viruses that cause cancer. She was the first woman appointed to Royal Postgraduate Medical School, Hammersmith Hospital. In 1980 she completed the sequence of the poliovirus, the longest piece of eukaryotic DNA to be sequenced at that time. She devoted her life to understanding the Epstein-Barr virus, the cause of Burkitt's Lymphoma, a deadly form of cancer. 2016-06-13T00:00:00+0000Smithies was a British-born American geneticist and physical biochemist. He first made his mark in 1955 through his invention of starch gel electrophoresis, a technique used to study human protein variation. Later on, in the 1980s he developed a method for targeted gene replacement in mice, now known as gene targeting, for which he was awarded the Nobel Prize for Medicine in 2007. His method paved the way to the creation of thousands of lines of mice carrying desired genetic mutations. Such mice are now widely used to investigate the role of many different genes in human health and disease. 2017-01-10T00:00:00+0000Discovery made as a result of study of 177 members of the Old Order of Amish community in Indiana. S. Khan, et al, 'A null mutation in SERPINE1 protects against biological aging in humans', Science Advances, 3/11 (2017), DOI: 10.1126/sciadv.aao16172017-11-15T00:00:00+0000Sulston was a biologist. He played a central role in sequencing the genome of the Caenorhabditis elegans, a transparent nematode (roundworm). It was the first animal to have its genome sequenced. Based on his work with the nematode Sulston helped set up the project to sequence the human genome which he did as director of the Sanger Centre. The first draft of the human genome sequence was completed in 2000. Sulston shared the Nobel Prize in 2002 for identifying how genes regulate the life cycle of cells through apoptosis. 2018-03-09T00:00:00+0000A team of scientists managed to engineer mice to express Cas9 and a DNA sequence needed for the gene drive, called a cassette, which encoded a guide RNA that targets a sequence in the TYR gene which affects the mouse coat colour. This provided a means of tracking the frequency of the genetic modification over several generations of mice. The work was published in HA Grunwald et al. 'Super-Mendelian inheritance mediated by CRISPR–Cas9 in the female mouse germline', Nature, January 23, 2019.2019-01-23T00:00:00+0000Born in South Africa, Brenner was a geneticist and biologist who shared the 2002 Nobel Prize for Medicine for helping to discover how genes regulate tissue and organ development. Using the roundworm Caenorhabditis elegans as a model organism, Brenner demonstrated that triplets of nucleotides within RNA encode the individual amino acids of a protein, and signals when protein manufacture should stop. 2019-04-05T00:00:00+0000
Date Event People Places Sciences
2012European approval of decatabine (Dacogen) for treatment of acute myeloid leukaemia  Epigenetics, Oncology
10 Mar 2013Frank Ruddle died in New Haven, ConnecticutRuddleYale UniversityGenetics, Transgenic animals, Cloning
Apr 2015Chinese regulatory authorities approved Chidamide, a histone deactylase inhibitor, for peripheral T cell lymphoma  Epigenetics, Oncology
27 Aug 2015Experiments with mice showed that azacytidine treatment enhanced the responsiveness of tumors to anti–CTLA-4 therapy  Cancer immunotherapy, Epigenetics, Immune checkpoint inhibitors, Oncology
13 Jun 2016Beverly Griffin diedGriffinImperial CollegeDNA sequencing, genetics, oncology, virology
10 Jan 2017Oliver Smithies diedSmithiesUniversity of Washington, University of North CarolinaGenetics, Transgenic animals
15 Nov 2017Rare mutation of gene called Serpine 1 discovered to protect against biological ageing processKhan, Shah, Klyachko, Baldridge, Eren, Place, Aviv, Puterman, Lloyd-Jones, Heiman, Miyata, Gupta, Shapiro, VaughanNorthwestern University, University of British Columbia, New Jersey Medical School, Tohoku University, DNA sequencing, Genetics, Genomics
9 Mar 2018John E Sulson diedSulstonLaboratory of Molecular Biology, Sanger InstituteCell, Genetics, DNA sequencing
23 Jan 2019CRISPR-Cas9 used to control genetic inheritance in miceGrunwald, Gntz, Poplawski, Xu, Bier, CooperUniversity of California San DiegoCRISPR-Cas9, Genetics, Transgenic animals
5 Apr 2019Sydney Brenner diedBrennerLaboratory of Molecular BiologyGenetics


European approval of decatabine (Dacogen) for treatment of acute myeloid leukaemia

10 Mar 2013

Frank Ruddle died in New Haven, Connecticut

Apr 2015

Chinese regulatory authorities approved Chidamide, a histone deactylase inhibitor, for peripheral T cell lymphoma

27 Aug 2015

Experiments with mice showed that azacytidine treatment enhanced the responsiveness of tumors to anti–CTLA-4 therapy

13 Jun 2016

Beverly Griffin died

10 Jan 2017

Oliver Smithies died

15 Nov 2017

Rare mutation of gene called Serpine 1 discovered to protect against biological ageing process

9 Mar 2018

John E Sulson died

23 Jan 2019

CRISPR-Cas9 used to control genetic inheritance in mice

5 Apr 2019

Sydney Brenner died