Vaccine: Timeline of key events
Mouseover the event title for a more detailed description of the event (if available). To search for particular terms in the description of the event enter the term in the box below 'Event' on the table and press 'enter'. Alternatively use the dropdown lists to filter by Person, Place or Science. Click here to clear the filter.
Date | Event | People | Places | Sciences |
---|---|---|---|---|
16 Jun 1975 | Merck filed US patent for process to isolate hepatitis B antigen | McAleer, Wasmuth | Merck | Vaccines, Infectious diseases |
Sep 1975 | Merck reported positive results from chimpanzee trials with hepatitis B vaccine containing inactivated HBsAg antigen | Hilleman, Buynak, Roehm, Tytell, Bertland | Merck | Vaccines, Infectious diseases |
1978 - 1980 | First clinical trials with plasma vaccine against hepatitis B | Szmuness, Hilleman | New York Medical Center | Vaccines, Infectious diseases |
1978 - 1986 | Low-cost plasma hepatitis B vaccine developed | Prince, Vnek | New York Blood Center | Vaccines |
Dec 1978 | Biogen filed preliminary UK patent for technique to clone hepatitis B DNA and antigens | Kenneth Murray | Biogen, University of Edinburgh | Recombinant DNA, Vaccines, Infectious diseases |
Feb 1979 | University of Edinburgh scientists published the successful isolation and cloning DNA fragments of the hepatitis B virus in Escherichia coli | Burrell, Mackay, Greenaway, Hofschneider, K Murray | University of Edinburgh, Microbiological Research Establishment, Biogen | Recombinant DNA, Vaccine |
May 1979 - Oct 1979 | Pasteur Institute scientists reported successful cloning of hepatitis B DNA in Escherichia coli | Galibert, Mandart, Fitoussi, Tiollais, Charnay, Hampe | Pasteur Institute | Recombinant DNA, Vaccines, Infectious diseases |
30 Aug 1979 | UCSF scientists announced the successful cloning and expression of HBsAg in Escherichia coli | Valenzuela, Gray, Quiroga, Zaldivar, Goodman, Rutter | University of California San Francisco, Merck | Recombinant DNA, Vaccines, Infectious diseases |
21 Dec 1979 | Biogen applied for European patent to clone fragment of DNA displaying hepatitis B antigen specificity | Murray | Biogen | Recombinant DNA, Vaccines, Infectious diseases |
1980 | US licensed first rabies vaccine for human use | Koprowski, Plotkin, Wiktor | Wistar Institute | Vaccines, Virology |
1980 | Pasteur Institute filed for US patent for fractionation method to purify HBsAg from plasma to produce hepatitis B vaccine | Tiollais | Pasteur Institute | Vaccines, Infectious diseases |
31 Jul 1980 | UCSF scientists published method to culture HBsAg antigens in cancer cells | Edman, Gray, Valenzuela, Rall, Rutter | University of California San Francisco | Vaccine, Recombinant DNA |
1981 - 1991 | US hepatitis B vaccination programme directed towards people identified at high risk | Vaccine | ||
Jul 1981 | UCSF and Merck filed patent to snthesise HBsAg in recombinant yeast | Rutter | University of California San Francisco, Merck | Vaccine, Recombinant DNA |
1982 | First plasma vaccines against hepatitis B licensed for market in US and Europe | Hilleman | Merieux, Institute Pasteur, Merck | Vaccines, Infectious diseases |
1982 | South Korea government launched nationwide hepatitis B immunisation programme | Vaccines | ||
1 Jun 1984 | Genetically engineered vaccine against hepatitis B reported to have positive trial results | Scolnick, McLean, West, McAleer , Miller, Buynak | Merck, University California San Francisco | Recombinant DNA, Vaccines, Infectious diseases |
Jul 1984 | Taiwan launched nationwide hepatitis B vaccination programme | Vaccine | ||
8 Sep 1985 | John F Enders died | Enders | Children's Hospital Boston | Virology, Vaccines, Infectious diseases |
1986 | Low-cost plasma vaccine against hepatitis B approved in Indonesia | Vaccines, Infectious diseases | ||
16 Jun 1975
Merck filed US patent for process to isolate hepatitis B antigen
Sep 1975
Merck reported positive results from chimpanzee trials with hepatitis B vaccine containing inactivated HBsAg antigen
1978 - 1980
First clinical trials with plasma vaccine against hepatitis B
1978 - 1986
Low-cost plasma hepatitis B vaccine developed
Dec 1978
Biogen filed preliminary UK patent for technique to clone hepatitis B DNA and antigens
Feb 1979
University of Edinburgh scientists published the successful isolation and cloning DNA fragments of the hepatitis B virus in Escherichia coli
May 1979 - Oct 1979
Pasteur Institute scientists reported successful cloning of hepatitis B DNA in Escherichia coli
30 Aug 1979
UCSF scientists announced the successful cloning and expression of HBsAg in Escherichia coli
21 Dec 1979
Biogen applied for European patent to clone fragment of DNA displaying hepatitis B antigen specificity
1980
US licensed first rabies vaccine for human use
1980
Pasteur Institute filed for US patent for fractionation method to purify HBsAg from plasma to produce hepatitis B vaccine
31 Jul 1980
UCSF scientists published method to culture HBsAg antigens in cancer cells
1981 - 1991
US hepatitis B vaccination programme directed towards people identified at high risk
Jul 1981
UCSF and Merck filed patent to snthesise HBsAg in recombinant yeast
1982
First plasma vaccines against hepatitis B licensed for market in US and Europe
1982
South Korea government launched nationwide hepatitis B immunisation programme
1 Jun 1984
Genetically engineered vaccine against hepatitis B reported to have positive trial results
Jul 1984
Taiwan launched nationwide hepatitis B vaccination programme
8 Sep 1985
John F Enders died
1986
Low-cost plasma vaccine against hepatitis B approved in Indonesia
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